Biomed Eng Lett.  2019 Aug;9(3):311-325. 10.1007/s13534-019-00118-8.

Optical coherence tomography angiography in preclinical neuroimaging

Affiliations
  • 1School of Electrical and Electronics Engineering, College of ICT Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 06974, Republic of Korea. cecc78@cau.ac.kr

Abstract

Preclinical neuroimaging allows for the assessment of brain anatomy, connectivity, and function in laboratory animals, such as mice and this imaging field has been a rapidly growing aimed at bridging the translation gap between animal and human research. The progress in the animal research could be accelerated by high-resolution in vivo optical imaging technologies. Optical coherence tomography-based angiography (OCTA) estimates the scattering from moving red blood cells, providing the visualization of functional micro-vessel networks within tissue beds in vivo without a need for exogenous contrast agents. Recent advancement of OCTA methods have expanded its application to neuroimaging of small animal models of brain disorders. In this paper, we overview the recent development of OCTA techniques for blood flow imaging and its preclinical applications in neuroimaging. In specific, a summary of preclinical OCTA studies for traumatic brain injury, cerebral stroke, and aging brain on mice is reviewed.

Keyword

Optical coherence tomography; Angiography; Preclinical neuroimaging, small animal models; Traumatic brain injury, stroke, aging

MeSH Terms

Aging
Angiography*
Animal Experimentation
Animals
Animals, Laboratory
Brain
Brain Diseases
Brain Injuries
Contrast Media
Erythrocytes
Humans
Mice
Models, Animal
Neuroimaging*
Optical Imaging
Stroke
Tomography, Optical Coherence*
Contrast Media
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