Korean J Head Neck Oncol.  2019 Nov;35(2):45-49. 10.21593/kjhno/2019.35.2.45.

A Case of Large Cell Neuroendocrine Carcinoma of the Maxillary Sinus

• Lee YJ
• Jeong JH
• Oh YH
• Ji YB

• KMID: 2469235
• DOI: http://doi.org/10.21593/kjhno/2019.35.2.45

Abstract

Large cell neuroendocrine carcinoma is a rare epithelial neuroendocrine malignancy and is preferentially located in gastrointestinal tract and pancreas. Cases of large cell neuroendocrine carcinoma have been reported in many other locations, including the thymus, gallbladder, prostate, larynx, salivary glands, nasopharynx, tonsil and mastoid. However, primary sinonasal large cell neuroendocrine carcinoma never have been reported in Korea. We experienced a case of primary large cell neuroendocrine carcinoma arising from left maxillary sinus recently. A 82-year-old male patient presented with nasal obstruction and epistaxis. The biopsy revealed large cell neuroendocrine carcinoma with poor differentiation. After a general evaluation, the patient was staged as cT3N0M0. The patient was treated by combined radiotherapy and chemotherapy. We report this rare case with literature review.

Keyword

Large cell neuroendocrine carcinoma; Paranasal sinus

MeSH Terms

Aged, 80 and over
Biopsy
Carcinoma, Neuroendocrine*
Drug Therapy
Epistaxis
Gallbladder
Gastrointestinal Tract
Humans
Korea
Larynx
Male
Mastoid
Maxillary Sinus*
Nasal Obstruction
Nasopharynx
Palatine Tonsil
Pancreas
Prostate
Radiotherapy
Salivary Glands
Thymus Gland