Genomics Inform.  2019 Dec;17(4):e36. 10.5808/GI.2019.17.4.e36.

Long non-coding RNA linc00152 acting as a promising oncogene in cancer progression

• Seo D
• Kim D
• Kim W

• KMID: 2468862
• DOI: http://doi.org/10.5808/GI.2019.17.4.e36

Abstract

The incidence and mortality rate of cancer continues to gradually increase, although considerable research effort has been directed at elucidating the molecular mechanisms underlying biomarkers responsible for tumorigenesis. Accumulated evidence indicates that the long non-coding RNAs (lncRNAs), which are transcribed but not translated into functional proteins, contribute to cancer development. Recently, linc00152 (an lncRNA) was identified as a potent oncogene in various cancer types, and shown to be involved in cancer cell proliferation, invasiveness, and motility by sponging tumor-suppressive microRNAs acting as a competing endogenous RNA, binding to gene promoters acting as a transcriptional regulator, and binding to functional proteins. In this review, we focus on the oncogenic role of linc00152 in tumorigenesis and provided an overview of recent clinical studies on the effects of linc00152 expression in human cancers.

Keyword

linc00152; long non-coding RNA; oncogene; tumorigenesis

MeSH Terms

Biomarkers
Carcinogenesis
Cell Proliferation
Humans
Incidence
MicroRNAs
Mortality
Oncogenes*
RNA
RNA, Long Noncoding*
Biomarkers
MicroRNAs
RNA
RNA, Long Noncoding