Prog Med Phys.  2019 Dec;30(4):104-111. 10.14316/pmp.2019.30.4.104.

Dosimetric Effects of Air Pocket during Magnetic Resonance-Guided Adaptive Radiation Therapy for Pancreatic Cancer

• Jin H
• Kim DY
• Park JM
• Kang HC
• Chie EK
• An HJ

• KMID: 2468171
• DOI: http://doi.org/10.14316/pmp.2019.30.4.104

Abstract

PURPOSE
Online magnetic resonance-guided adaptive radiotherapy (MRgART), an emerging technique, is used to address the change in anatomical structures, such as treatment target region, during the treatment period. However, the electron density map used for dose calculation differs from that for daily treatment, owing to the variation in organ location and, notably, air pockets. In this study, we evaluate the dosimetric effect of electron density override on air pockets during online ART for pancreatic cancer cases.
METHODS
Five pancreatic cancer patients, who were treated with MRgART at the Seoul National University Hospital, were enrolled in the study. Intensity modulated radiation therapy plans were generated for each patient with 60Co beams on a ViewrayTM system, with a 45 Gy prescription dose for stereotactic body radiation therapy. During the treatment, the electron density map was modified based on the daily MR image. We recalculated the dose distribution on the plan, and the dosimetric parameters were obtained from the dose volume histograms of the planning target volume (PTV) and organs at risk.
RESULTS
The average dose difference in the PTV was 0.86Gy, and the observed difference at the maximum dose was up to 2.07 Gy. The variation in air pockets during treatment resulted in an under- or overdose in the PTV.
CONCLUSIONS
We recommend the re-contouring of the air pockets to deliver an accurate radiation dose to the target in MRgART, even though it is a time-consuming method.

Keyword

MR-guided radiotherapy; Adaptive radiotherapy; Interfractional motion; Pancreatic neoplasm; Air pocket

MeSH Terms

Humans
Methods
Organs at Risk
Pancreatic Neoplasms*
Prescriptions
Radiotherapy
Seoul