Radiat Oncol J.  2018 Dec;36(4):254-264. 10.3857/roj.2018.00500.

Management for locally advanced cervical cancer: new trends and controversial issues

• Cho O
• Chun M

• KMID: 2434314
• DOI: http://doi.org/10.3857/roj.2018.00500

Abstract

This article reviewed new trends and controversial issues, including the intensification of chemotherapy and recent brachytherapy (BT) advances, and also reviewed recent consensuses from different societies on the management of locally advanced cervical cancer (LACC). Intensive chemotherapy during and after radiation therapy (RT) was not recommended as a standard treatment due to severe toxicities reported by several studies. The use of positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI) for pelvic RT planning has increased the clinical utilization of intensity-modulated radiation therapy (IMRT) for the evaluation of pelvic lymph node metastasis and pelvic bone marrow. Recent RT techniques for LACC patients mainly aim to minimize toxicities by sparing the normal bladder and rectum tissues and shortening the overall treatment time by administering a simultaneous integrated boost for metastatic pelvic lymph node in pelvic IMRT followed by MRI-based image guided adaptive BT.

Keyword

Uterine cervical neoplasms; Intensity-modulated radiotherapy; Drug therapy; Brachytherapy

MeSH Terms

Bone Marrow
Brachytherapy
Consensus
Drug Therapy
Electrons
Humans
Lymph Nodes
Magnetic Resonance Imaging
Neoplasm Metastasis
Pelvic Bones
Radiotherapy, Intensity-Modulated
Rectum
Urinary Bladder
Uterine Cervical Neoplasms*