Asian Oncol Nurs.  2019 Dec;19(4):204-213. 10.5388/aon.2019.19.4.204.

Oxaliplatin-induced Peripheral Neuropathy, Symptoms, Distress and Quality of Life among Korean Patients with Gastrointestinal Cancer

• Jung HJ
• Ahn SJ
• Yang YR
• Kim KA
• Shin SJ
• Jung MK
• Chu SH

• KMID: 2467635
• DOI: http://doi.org/10.5388/aon.2019.19.4.204

Abstract

PURPOSE
This study was conducted to identify the level of oxaliplatin-induced peripheral neuropathy (OIPN), symptoms, distress, and quality of life (QoL) in gastrointestinal (GI) cancer patients and to identify the factors influencing QoL.
METHODS
A total of 123 patients were recruited for this cross-sectional study. Surveys used were the Therapy-Induced Neuropathy Assessment Scale (TNAS) for OIPN, the MD Anderson Symptom Inventory (MDASI-GI) for general symptoms associated with gastrointestinal cancer and its treatment, a distress thermometer, and the Euro Quality of Life Questionnaire 5-Dimensional Classification (EQ-5D) for QoL.
RESULTS
The patients were classified into three groups based on their treatment completion time (current, completed less than one year ago, completed more than one year ago). The scores of MDASI-GI and distress were significantly lower in patients who had completed chemotherapy compared to those who were undergoing treatment (p=.04 and .02 respectively). However, TNAS score was significantly higher in patients who completed chemotherapy less than one year ago than the other two groups (p=.001). In multivariate regression models, the OIPN and distress or general symptoms were identified as factors associated with QoL.
CONCLUSION
In this study, we identified the symptoms that are factors related to the QoL in patients with GI cancer. In particular, the symptoms of OIPN are reported at significantly increased levels for patients who have finished chemotherapy less than one year ago, so efforts to prevent and manage the symptoms of OIPN are needed in this timeframe. To improve QoL of patients with GI cancer, continuous attention and care are required not only during the treatment of cancer but also after the completion of treatment.

Keyword

Oxaliplatin; Symptom; Peripheral neuropathy; Distress; Quality of life

MeSH Terms

Classification
Cross-Sectional Studies
Drug Therapy
Gastrointestinal Neoplasms*
Humans
Peripheral Nervous System Diseases*
Quality of Life*
Thermometers

Figure

• 

  Fig. 1 The score of symptom severity. The patients were classified into three groups based on their treatment completion time (undergoing, completed within one year, completed more than one year before). Except for numbness/tingling and disturbed sleep, there was no difference in symptom severity among groups.

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