J Korean Acad Nurs.  2015 Oct;45(5):661-670. 10.4040/jkan.2015.45.5.661.

Disturbance in ADL from Chemotherapy-induced Peripheral Neuropathy and Quality of Life in Cancer Patients: The Mediating Effect of Psychological Distress

• Kim KY
• Lee SH
• Kim JH
• Oh PJ

• KMID: 2363091
• DOI: http://doi.org/10.4040/jkan.2015.45.5.661

Abstract

PURPOSE
The purpose of this study was to examine the mediation of psychological distress in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life in order to provide a basis for planning nursing interventions to improve the quality of life in cancer patients.
METHODS
A purposive sample of 130 patients treated with chemotherapy were recruited in the cross-sectional survey design. Data were collected using self-report questionnaires. The instruments were the Chemotherapy Induced Peripheral Neuropathy Assessment Tool (CIPNAT), Hospital Anxiety Depression Scale (HADS), and Functional Assessment of Cancer Therapy-General (FACT-G).
RESULTS
The mean score for disturbance in ADL from chemotherapy induced peripheral neuropathy was 3.30. Overall quality of life was 2.48. The mean score was 1.04 for psychological distress. The prevalence was 35.4% for anxiety and 47.7% for depression. There were significant correlations among the three variables, disturbance in ADL from chemotherapy induced peripheral neuropathy, psychosocial distress, and quality of life. Psychosocial distress had a complete mediating effect (beta= -.74, p <.001) in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life (Sobel test: Z= -6.11, p <.001).
CONCLUSION
Based on the findings of this study, nursing intervention programs focusing on disturbance of ADL management, and decrease of psychological distress are highly recommended to improve quality of life in cancer patients.

Keyword

Quality of life; Peripheral neuropathy; Neoplasm; Depression

MeSH Terms

*Activities of Daily Living
Adult
Aged
Antineoplastic Agents/*adverse effects/therapeutic use
Anxiety
Cross-Sectional Studies
Depression/etiology
Female
Humans
Male
Middle Aged
Neoplasms/drug therapy/pathology/*psychology
Peripheral Nervous System Diseases/*etiology
*Quality of Life
Self Report
Stress, Psychological
Surveys and Questionnaires
Antineoplastic Agents

Figure

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  Figure 1 Mediating effect of psychological distress in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life.

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