Pediatr Infect Vaccine.  2019 Dec;26(3):140-147. 10.14776/piv.2019.26.e22.

Changing Susceptibility of Staphylococcus aureus in Children with Skin and Soft Tissue Infections: a Single Center Experience from 2010 to 2018

• Cho YS
• Lee SH
• Lee TJ

• KMID: 2466458
• DOI: http://doi.org/10.14776/piv.2019.26.e22

Abstract

PURPOSE
Staphylococcus aureus is a major cause of skin and soft tissue infections (SSTIs). This study aimed to determine the temporal trends in antibiotic susceptibility of S. aureus in SSTI patients aged <19 years.
METHODS
This retrospective observational study was conducted in pediatric patients with SSTI caused by community-associated S. aureus. Microbiologic and demographic data were collected, and the trends of antibiotic susceptibility results were evaluated.
RESULTS
From January 2010 to December 2018, a total of 807 S. aureus isolates were included. An overall increase in susceptibility of isolates to oxacillin was noted (P<0.001), with 75.0% of isolates being oxacillin-susceptible in 2018. S. aureus remained highly susceptible to trimethoprim/sulfamethoxazole and tetracycline, with 97.6% and 95.2% isolate susceptibility in 2018, respectively. Isolates from younger children aged 1 to 5 years had a significantly lower rate of susceptibility to oxacillin than older children aged 6 to 18 years (53.4% vs. 75.0%, P<0.001).
CONCLUSIONS
The proportion of methicillin-resistant S. aureus isolates appears to decrease in pediatric patients with community-associated SSTI caused by S. aureus. Clinicians should be aware of regional susceptibility patterns when choosing empirical regimens.

Keyword

Staphylococcus aureus; Staphylococcal skin infections; Methicillin-resistant

MeSH Terms

Child*
Humans
Methicillin Resistance
Observational Study
Oxacillin
Retrospective Studies
Skin*
Soft Tissue Infections*
Staphylococcal Skin Infections
Staphylococcus aureus*
Staphylococcus*
Tetracycline
Oxacillin
Tetracycline

Figure

• 

  Fig. 1 Schematic diagram describing pediatric patients with skin and soft tissue infections included in the study. *Only the first isolate from each patient per hospital admission was included; †Three patients had history of surgery or hospitalization in the 12 months preceding the culture and had an invasive device at the time of evaluation.

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