Korean J Pediatr Infect Dis.  2009 Dec;16(2):150-161.

A Review of Staphylococcus aureus Infections in Children with an Emphasis on Community-associated Methicillin-resistant S. aureus Infections

• Choe YJ
• Lee SY
• Sung JY
• Yang MA
• Lee JH
• Oh CE
• Lee J
• Choi EH
• Lee HJ

Abstract

PURPOSE
Staphylococcus aureus causes a variety of infections, ranging from benign skin infections to fatal invasive infections. Recently, methicillin-resistant S. aureus (MRSA) infections have emerged in patients who do not have established risk factors. This study was conducted to characterize S. aureus infections in children with an emphasis on community- associated MRSA infections at a tertiary care pediatric facility during a 3-year period.
METHODS
Four hundred twenty-nine cases of S. aureus infections diagnosed at the Seoul National University Children's Hospital between January 2004 and December 2006 were retrospectively reviewed. The cases were classified as hospital- onset (HO) or community-onset (CO), healthcare-associated (HA), or community-associated (CA) infections.
RESULTS
Among the 206 cases <1 year of age, 72%, 7%, and 21% were HO-HA, CO-HA, and CA infections, respectively, as compared to 48%, 28%, and 24% among the 223 cases >1 year of age. The proportion of CO-HA infections among HA infections (8.6% vs. 37.1%, P<0.001) and the proportion of HA infections among the CO infections (24.5% vs. 54.3%, P<0.001) were greater in older children than in infants. Overall, 57% of the isolates were methicillin-resistant. Twenty-nine (30%) of 96 CA strains were MRSA, and the most common site of CA-MRSA infection was the skin and soft tissues (26 cases).
CONCLUSION
The methicillin resistance rate of S. aureus from CA infections was high and CA-MRSA was most often associated with skin and soft tissue infections.

Keyword

Staphylococcus aureus; Methicillin-resistant Staphylococcus aureus (MRSA); Community-associated Staphylococcus aureus (CA-MRSA); Childhood; Korea

MeSH Terms

Child
Humans
Infant
Korea
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus
Retrospective Studies
Risk Factors
Skin
Soft Tissue Infections
Staphylococcus
Staphylococcus aureus
Tertiary Healthcare