Korean J Anesthesiol.  2019 Dec;72(6):583-591. 10.4097/kja.19336.

Effects of propofol, desflurane, and sevoflurane on respiratory functions following endoscopic endonasal transsphenoidal pituitary surgery: a prospective randomized study

• Oguz A
• Akcil EF
• Tunali Y
• Vehid H
• Dilmen OK

• KMID: 2465728
• DOI: http://doi.org/10.4097/kja.19336

Abstract

BACKGROUND
General anesthesia with intravenous or inhalation anesthetics reduces respiratory functions. We investigated the effects of propofol, desflurane, and sevoflurane on postoperative respiratory function tests.
METHODS
This single-center randomized controlled study was performed in a university hospital from October 2015 to February 2017. Ninety patients scheduled for endoscopic endonasal transsphenoidal pituitary surgery were randomly categorized into either of these three groups: propofol (n = 30, the Group TIVA), desflurane (n = 30, the Group D) or sevoflurane (n = 30, the Group S). We analyzed the patients before, after, and 24 h following surgery, to identify the following parameters: forced expiratory volume in 1 second (FEV₁) %, forced vital capacity (FVC) %, FEV₁/FVC, and arterial blood gases (ABG). Furthermore, we also recorded the intraoperative dynamic lung compliance and airway resistance values.
RESULTS
We did not find any significant differences in FEV₁ values (primary outcome) among the groups (P = 0.336). There was a remarkable reduction in the FEV₁ and FVC values in all groups postoperatively relative to the baseline (P < 0.001). The FVC, FEV₁/FVC, ABG analysis, compliance, and airway resistance were similar among the groups. Intraoperative dynamic compliance values were lower at the 1st and 2nd hours than those immediately after intubation (P < 0.001).
CONCLUSIONS
We demonstrated that propofol, desflurane, and sevoflurane reduced FEV₁ and FVC values postoperatively, without any significant differences among the drugs.

Keyword

Airway resistance; Desflurane; Lung compliance; Propofol; Respiratory function tests; Sevoflurane

MeSH Terms

Airway Resistance
Anesthesia, General
Anesthetics, Inhalation
Compliance
Forced Expiratory Volume
Gases
Humans
Intubation
Lung Compliance
Propofol*
Prospective Studies*
Respiratory Function Tests
Vital Capacity
Anesthetics, Inhalation
Gases
Propofol