J Mov Disord.  2019 Sep;12(3):172-176. 10.14802/jmd.19004.

The Impact of Impulsivity on Quality of Life in Early Drug-Naïve Parkinson's Disease Patients

Affiliations
  • 1Department of Neurology, College of Medicine, The Catholic University of Korea, Seoul, Korea. neuronet@catholic.ac.kr

Abstract


OBJECTIVE
Impulse control disorders (ICDs) in Parkinson's disease (PD) are mostly related to dopamine replacement therapy (DRT); however, drug-naïve PD patients have also frequently experienced impulsivity. This phenomenon makes clinicians hesitate treating patients with DRT. In this study, we assessed the effect of impulsivity on quality of life (QOL) in drug-naïve PD patients.
METHODS
Two hundred three newly diagnosed, nonmedicated PD patients were enrolled, and they received structured clinical interviews, physical examinations and validated questionnaires to evaluate motor and nonmotor symptoms and QOL. Impulsivity was evaluated using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS).
RESULTS
Thirty-eight patients (18.7%) had impulsivity with QUIP-RS scores ≥ 1 and 4 patients (2.0%) were diagnosed with combined ICDs. Motor and nonmotor symptoms were significantly correlated with the Parkinson's Disease Questionnaire-39 summary index. Female sex and QUIP-RS scores were also correlated with QOL in drug-naïve PD patients.
CONCLUSION
The results of the present study showed that impulsivity negatively influences QOL in early drug-naïve PD patients. In addition, more severe motor and nonmotor symptoms were also associated with lower QOL. Such findings complicate treatment but provide valuable information for managing early PD.

Keyword

Impulse control disorder; Impulsivity; Parkinson's disease; Quality of life

MeSH Terms

Disruptive, Impulse Control, and Conduct Disorders
Dopamine
Female
Humans
Impulsive Behavior*
Parkinson Disease*
Physical Examination
Quality of Life*
Dopamine
Full Text Links
  • JMD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error