Psychiatry Investig.  2019 Oct;16(10):759-765. 10.30773/pi.2019.06.17.

An Exploration of the Oryza sativa L. Cyanidin-3-glucoside on the Cognitive Function in Older Adults with Subjective Memory Impairment

• Joo SH
• Hahn C
• Lim HK
• Yoon KD
• Yoon SH
• Lee CU

• KMID: 2462775
• DOI: http://doi.org/10.30773/pi.2019.06.17

Abstract

OBJECTIVE
Cyanidin-3-glucoside (C3G), is a component of anthocyanin, have been considered to positively influence cognition and be beneficial for the prevention and treatment of dementia. We aimed to assess the safety and efficacy of cyanidin-3-glucoside-rich Oryza sativa L. (black rice) extract on cognitive function.
METHODS
A 12-weeks double-blind randomized, placebo controlled trial assessed safety and cognitive outcomes in participants with subjective memory impairment (n=48) following consumption of 6 black rice extract capsules or a placebo. Cognitive function was assessed using the ADAS-cog and the CERAD-K. Subjective memory impairment also assessed. Safety was assessed by hematologic blood test, urine analysis, and participant reports of adverse events.
RESULTS
There was significant improvement on subjective memory in intervention group. There was no statistically significant difference in objective cognitive outcomes following 12 weeks of consuming black rice extract. ADAS-cog scores, however, trended toward improvement in the intervention group compared to the placebo group. There was no adverse event.
CONCLUSION
Although significant improvement in objective cognitive function was not proved, we found that C3G-rich Oryza sativa L. extract improves subjective memory in this study. Therefore the results may be informative of the possible effectiveness of the C3G-rich Oryza sativa L. on cognitive function.

Keyword

Oryza sativa L; Cyanidin-3-glucoside; Cognitive function; Safety

MeSH Terms

Adult*
Anthocyanins
Capsules
Cognition*
Dementia
Hematologic Tests
Humans
Memory*
Oryza*
Anthocyanins
Capsules