Allergy Asthma Immunol Res.  2020 Jan;12(1):4-23. 10.4168/aair.2020.12.1.4.

MicroRNAs in Asthma and Respiratory Infections: Identifying Common Pathways

Affiliations
  • 1Allergy and Clinical Immunology Unit, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece. nikolaos.papadopoulos@manchester.ac.uk
  • 2Division of Infection, Inflammation and Respiratory Medicine, University of Manchester, Manchester, United Kingdom.

Abstract

MicroRNAs (miRs) are single-stranded RNAs of 18-25 nucleotides. These molecules regulate gene expression at the post-transcriptional level; several of these are differentially expressed in asthma as well as in viral acute respiratory infections (ARIs), the main triggers of acute asthma exacerbations. In recent years, miRs have been studied in order to discover drug targets as well as biomarkers for diagnosis, disease severity and prognosis. We describe recent findings on miR expression and function in asthma and their role in the regulation of viral ARIs, according to cell tissue specificity and asthma severity. By combining the above information, we identify miRs that may be important in virus-induced asthma exacerbations. This is the first attempt to link miR profiles of asthmatic patients and ARI-induced miRs, addressing the question of whether there might be a specific miR deficit in asthmatic subjects that make them more susceptible and/or reactive to infection.

Keyword

MicroRNAs; asthma; respiratory infections, virus; disease progression; inflammation

MeSH Terms

Asthma*
Biomarkers
Diagnosis
Disease Progression
Gene Expression
Humans
Inflammation
MicroRNAs*
Nucleotides
Organ Specificity
Prognosis
Respiratory Tract Infections*
RNA
Biomarkers
MicroRNAs
Nucleotides
RNA
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