Int J Oral Biol.  2019 Sep;44(3):101-107. 10.11620/IJOB.2019.44.3.101.

Antimicrobial activity of Garcinia mangostana L. ethanol extract against Cutibacterium acnes and Staphylococcus aureus

  • 1Korean Collection for Oral Microbiology, College of Dentistry, Chosun University, Gwangju 61452, Republic of Korea.
  • 2Department of Oral Biochemistry, College of Dentistry, Chosun University, Gwangju 61452, Republic of Korea.
  • 3Medi Bio Lab Co., Ltd., Seoul 08389, Republic of Korea.


The purpose of this study was to investigate the antimicrobial activity of the ethanol extract of Garcinia mangostana L. (mangosteen) against Cutibacterium acnes (6 strains) and Staphylococcus aureus (6 strains). The antimicrobial activity of the mangosteen extract was evaluated based on its minimal bactericidal concentration. Cytotoxicity of the mangosteen extract against human embryonic kidney 293 (HEK 293) cells was determined using the cell counting method. The data showed that the mangosteen extract was not toxic to HEK 293 cells at a concentration of up to 16 µg/mL and killed 87.0% and 99.9% of C. acnes and S. aureus after 10 minutes and 1 hour of treatment, respectively. These results suggest that ethanol extract of mangosteen can be used as an anti-acne agent.


Garcinia mangostana; Antimicrobial effect; Cutibacterium acnes; Staphylococcus aureus
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