Int J Oral Biol.  2018 Sep;43(3):129-132. 10.11620/IJOB.2018.43.3.129.

Antimicrobial Effect of Ethanol Extract of Garcinia mangostana L. against Enterococcus faecalis Isolated from Human Oral Cavity

• Park TY
• Lim YK
• Lee DS
• Kook JK

• KMID: 2437349
• DOI: http://doi.org/10.11620/IJOB.2018.43.3.129

Abstract

Enterococcus faecalis is a major causative agent of endodontic treatment failure. The purpose of this study was to investigate bactericidal effects of ethanol extract of Garcinia mangostana L. (mangosteen extract) on five strains of E. faecalis that were isolated from human oral cavities. The bactericidal effects of mangosteen extract were assessed by measurement of minimum bactericidal concentration (MBC) value. The cytotoxicity of mangosteen extract on immortalized human gingival fibroblasts, hTERT-hNOF, was determined based on cell counting method. The data revealed the MBC value of mangosteen extract against the E. faecalis strains was 4 µg/ml. Additionally, the cell viability of mangosteen extract on hTERT-hNOF was 83.7-89.1% at the 1 to 16 µg/ml. These findings indicated that mangosteen extract could be used as a root canal cleaner during management of endodontic treatment failure caused by E. faecalis.

Keyword

mangosteen extract; Enterococcus faecalis; bactericidal effect

MeSH Terms

Cell Count
Cell Survival
Dental Pulp Cavity
Enterococcus faecalis*
Enterococcus*
Ethanol*
Fibroblasts
Garcinia mangostana*
Garcinia*
Humans*
Methods
Mouth*
Treatment Failure
Ethanol