Radiat Oncol J.  2019 Sep;37(3):207-214. 10.3857/roj.2019.00136.

Prognostic factors in hepatocellular carcinoma patients with bone metastases

• Kim S
• Choi Y
• Kwak DW
• Lee HS
• Hur WJ
• Baek YH
• Lee SW

• KMID: 2460746
• DOI: http://doi.org/10.3857/roj.2019.00136

Abstract

PURPOSE
To identify the prognostic factors that could influence survival and to compare prognoses of the patients with the number of the risk factors that might assist in the adequate management of hepatocellular carcinoma (HCC) patients with bone metastases that showed a heterogeneous range of survival.
MATERIALS AND METHODS
A total of 41 patients, treated with radiotherapy (RT) for bone metastases from HCC from 2014 to 2017, were enrolled retrospectively. Survival was determined by the Kaplan-Meier method from the start of the RT for metastatic bone lesions. Pre-RT clinical features were evaluated and their influences on survival were analyzed. The significant factors were considered to compare survivals according to the number of prognostic factors.
RESULTS
Median follow-up was 6.0 months (range, 0.5 to 47.0 months). The median overall survival was 6.5 months, and the 1-year and 2-year survival rates were 35.5% and 13.5%, respectively. Multivariate analysis revealed that the Child-Pugh class A group, alpha-fetoprotein increased more than 30 ng/mL, and HCC size of more than 5 cm were associated with worse overall survival. The median survivals in HCC with none, 1, 2, and 3 of the aforementioned risk factors were 19.5, 9.0, 2.5, and 1.0 months, respectively (p < 0.05).
CONCLUSION
Our results show that the overall survivals were significantly different according to the number of the risk factors among HCC patients with bone metastases who showed various lengths of survival.

Keyword

Hepatocellular carcinoma; Bone metastasis; Prognosis; Triage; Radiotherapy

MeSH Terms

alpha-Fetoproteins
Carcinoma, Hepatocellular*
Follow-Up Studies
Humans
Methods
Multivariate Analysis
Neoplasm Metastasis*
Prognosis
Radiotherapy
Retrospective Studies
Risk Factors
Survival Rate
Triage
alpha-Fetoproteins