Cancer Res Treat.  2019 Oct;51(4):1285-1294. 10.4143/crt.2018.464.

Development of Protocol for Korean Lung Cancer Screening Project (K-LUCAS) to Evaluate Effectiveness and Feasibility to Implement National Cancer Screening Program

Affiliations
  • 1National Cancer Control Institute, National Cancer Center, Goyang, Korea. drheat@ncc.re.kr
  • 2Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.
  • 3Department of Diagnostic Radiology, National Cancer Center, Goyang, Korea.
  • 4Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
  • 5Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
  • 6Department of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea.
  • 7Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  • 8Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
  • 9Department of Family Medicine, Gachon University Gil Medical Center, Incheon, Korea.
  • 10Department of Internal Medicine, Pusan National University, Busan, Korea.

Abstract

PURPOSE
To reduce lung cancer mortality, lung cancer screening was recommended using low-dose computed tomography (LDCT) to high-risk population. A protocol for multicenter lung cancer screening pilot project was developed to evaluate the effectiveness and feasibility of lung cancer screening to implement National Cancer Screening Program in Korea.
MATERIALS AND METHODS
Multidisciplinary expert committee was comprised to develop a standardized protocol for Korean Lung Cancer Screening Project (K-LUCAS). K-LUCAS is a population-based single arm trial that targets high-risk population aged 55-74 years with at least 30 pack-year smoking history. LDCT results are reported by Lung-RADS suggested by American Radiology Society. Network-based system using computer-aided detection program is prepared to assist reducing diagnostic errors. Smoking cessation counselling is provided to all currently smoking participants. A small pilot test was conducted to check the feasibility and compliance of the protocols for K-LUCAS.
RESULTS
In pilot test, 256 were participated. The average age of participants was 63.2 years and only three participants (1.2%) were female. The participants had a smoking history of 40.5 pack-year on average and 53.9% were current smokers. Among them, 86.3% had willing to participate in lung cancer screening again. The average willingness to quit smoking among current smokers was 12.7% higher than before screening. In Lung-RADS reports, 10 (3.9%) were grade 3 and nine (3.5%) were grade 4. One participant was diagnosed as lung cancer.
CONCLUSION
The protocol developed by this study is assessed to be feasible to perform K-LUCAS in multicenter nationwide scale.

Keyword

Lung neoplasms; Mass screening; Low-dose computed tomography; Smokers; Pilot test

MeSH Terms

Arm
Compliance
Diagnostic Errors
Early Detection of Cancer*
Female
Humans
Korea
Lung Neoplasms*
Lung*
Mass Screening*
Mortality
Pilot Projects
Smoke
Smoking
Smoking Cessation
Smoke

Figure

  • Fig. 1. A summary of lung cancer screening procedure in Korean Lung Cancer Screening Project (K-LUCAS). (A) A summary of lung cancer screening procedure for National Cancer Screening Program (NCSP) participants. (B) A summary of lung cancer screening procedure for smoking cessation clinic visitors. LDCT, low-dose computed tomography.

  • Fig. 2. Network-based diagnosis supporting system using computer-aided detection (CAD) program in Korean Lung Cancer Screening Project (K-LUCAS). CT, computed tomography.

  • Fig. 3. Participant flow to screening in pilot test. K-LUCAS, Korean Lung Cancer Screening Project.

  • Fig. 4. Anxiety of lung cancer before and after lung cancer screening.


Cited by  2 articles

Evidence of National Lung Cancer Screening Program in Korea
Yeol Kim
Korean J Health Promot. 2019;19(4):161-165.    doi: 10.15384/kjhp.2019.19.4.161.

Cost Utility Analysis of a Pilot Study for the Korean Lung Cancer Screening Project
Juyoung Kim, Bogeum Cho, Seon-Ha Kim, Chang-Min Choi, Yeol Kim, Min-Woo Jo
Cancer Res Treat. 2022;54(3):728-736.    doi: 10.4143/crt.2021.480.


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