J Korean Ophthalmol Soc.  2019 Oct;60(10):915-921. 10.3341/jkos.2019.60.10.915.

Effect of 3% Diquafosol Tetrasodium on Tear Film Stability after Laser-assisted in situ Keratomileusis

• Kim CH
• Seong S
• Kim JK
• Choi JH
• Choe CM
• Choi TH
• Kim S

• KMID: 2460508
• DOI: http://doi.org/10.3341/jkos.2019.60.10.915

Abstract

PURPOSE
To evaluate the efficacy of 3% diquafosol tetrasodium (DQ) after laser-assisted in-situ keratomileusis (LASIK).
METHODS
This prospective randomized study included 150 eyes in 75 patients who were scheduled for LASIK. The patients in the 3% diquafosol tetrasodium (DQ) group (37 patients, 74 eyes) were instructed to apply one drop of DQ, six times daily post-op, while the patients in the 0.3% sodium hyaluronate (HA) group (38 patients, 76 eyes) were instructed to apply one drop of HA, six times daily post-op. A Schirmer test, tear film break-up time (BUT), corneal and conjunctival fluorescein staining score (FLSS), and ocular surface disease index (OSDI) were evaluated pre-op and at 1, 4, and 12 weeks post-op while the tear osmolarity was evaluated pre-op and at 4 and 12 weeks post-op.
RESULTS
There was no significant difference between the two groups regarding Schirmer test results or tear osmolarity and conjunctival FLSS. The BUT was significantly higher in the DQ group at 1 week and 12 weeks post-op. The corneal FLSS was significantly lower in the DQ group at 1 week, 4 weeks and 12 weeks post-op. The OSDI was significantly lower in the DQ group at 1 week post-op.
CONCLUSIONS
Use of 3% diquafosol tetrasodium after surgery improved ocular dryness and increased the tear film stability.

Keyword

Diquafosol; Dry eyes; Laser-assisted in-situ keratomileusis; Tear film stability

MeSH Terms

Fluorescein
Humans
Hyaluronic Acid
Keratomileusis, Laser In Situ
Osmolar Concentration
Prospective Studies
Tears*
Fluorescein
Hyaluronic Acid

Figure

• 

  Figure 1 Cornea and conjunctival fluorescein stain grading. The National Eye Institute/Industry grading system for grading fluorescein staining divides the corneal and conjunctival surfaces to help measure fluorescein uptake. A standardized grading system of 0 to 3 is used for each of the five areas on each cornea and each of the six areas on each conjunctiva.

• 

  Figure 2 Changes in Tear film break-up time (A), corneal fluorescein staining score (B), conjunctival fluorescein staining score (C), Schirmer test (D), tear osmolarity (E), and ocular surface disease index (F) in the 3% diquafosol tetrasodium and 0.3% sodium hyaluronate group before and after laser-assisted in-situ keratomileusis. ‘DQ’ is 3% diquafosol tetrasodium group, ‘HA’ is 0.3% sodium hyaluronate group. LASIK = laser-assisted in-situ keratomileusis. *Repeat measures analysis of variance test, p < 0.05 between 3% diquafosol tetrasodium and 0.3% sodium hyaluronate group.

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