J Korean Ophthalmol Soc.  2015 Mar;56(3):339-344. 10.3341/jkos.2015.56.3.339.

Clinical Efficacy of Topical 3% Diquafosol Tetrasodium in Short Tear Film Break-Up Time Dry Eye

• Jung HH
• Kang YS
• Sung MS
• Yoon KC

• KMID: 2339038
• DOI: http://doi.org/10.3341/jkos.2015.56.3.339

Abstract

PURPOSE
To evaluate the clinical efficacy of topical diquafosol tetrasodium 3% ophthalmic solution in patients with short tear film break-up time (BUT) dry eye.
METHODS
This prospective study involved 30 eyes in 30 patients with dry eye who had tear film BUT values < or =5 seconds and schirmer's 1 test > or =5 mm, and showed no improvement with non-preservative sodium hyaluronate (SH) 0.1% artificial tears. All patients were treated with topical diquafosol tetrasodium 3% 6 times a day, in addition to SH 0.1% artificial tears. Schirmer's 1 test, tear film BUT, keratoepitheliopathy score with fluorescein, conjunctival staining score with lissamine green, and Ocular surface disease index (OSDI) score were evaluated at before treatments, and 1 month and 3 months after treatments.
RESULTS
Significant improvements of tear film BUT and OSDI were observed at 1 month and 3 months after diquafosol tetrasodium 3% administration. At before treatment, and followed up at 1 and 3 months, tear film BUTs were 3.3 +/- 1.2, 4.4 +/- 1.0 (p < 0.01) and 4.9 +/- 1.1 seconds (p < 0.01), respectively, and OSDI scores were 43.5 +/- 24.4, 34.6 +/- 25.0 (p = 0.01) and 26.7 +/- 21.5 (p < 0.01), respectively. There were no significant changes of Schirmer's score, keratoepitheliopathy, and conjunctival staining score. After diquafosol tetrasodium 3% administration, severe adverse effects were not found in any of the patients.
CONCLUSIONS
Topical diquafosol tetrasodium 3% administration was shown to be an effective treatment for improvements of tear film stability and dry eye symptoms.

Keyword

Diquafosol tetrasodium 3%; Dry eye; Short tear film break-up time

MeSH Terms

Fluorescein
Humans
Hyaluronic Acid
Ophthalmic Solutions
Prospective Studies
Tears*
Fluorescein
Hyaluronic Acid
Ophthalmic Solutions

Figure

• 

  Figure 1. Changes of tear film and ocular surface parameters before and after treatment with topical 3% diquafosol tetrasodium. (A) Schirmer’s I test. (B) Tear film break-up time. (C) Corneal staining score. (D) Conjunctival staining score. * p < 0.05 compared with baseline; † p < 0.05 compared with 1 month after treatment.

Reference

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