J Korean Orthop Assoc.  1978 Mar;13(1):67-73. 10.4055/jkoa.1978.13.1.67.

Vitamin D Resistant Rickets

• Lee CJ
• Chang IY
• Park WC

• KMID: 2460403
• DOI: http://doi.org/10.4055/jkoa.1978.13.1.67

Abstract

The discovery and synthesis of vitamin D and the elucidation of the role of sunlight in the activation of the vitamin D precursors changed the syndromes of rickets from a therapeutic enigma to a socioeconomic and public health problem. Since Albright in 1937 first described vitamin D resistsnt rickets, which did not respond to treatment with the usual dose of vitamin D, it has progressively become a common form of rickets in practice. In addition, as the result of increasing understanding of renal physiology and careful investigation, a spectrum of renal tubular abnormalities have been identified which cause clinical rickets and which in many cases are insensitive to even large doses of vitamin D. We have reported a case of an unusual form of vitamin D resistant rickets which did not easily respond to treatment with high doses of vitamin D and was associated with hypocalcemia in multiple pathologic fractures in the lower extremities of the patient.

MeSH Terms

Familial Hypophosphatemic Rickets*
Fractures, Spontaneous
Humans
Hypocalcemia
Lower Extremity
Physiology
Public Health
Rickets
Sunlight
Vitamin D*
Vitamins*
Vitamin D
Vitamins