J Obes Metab Syndr.  2019 Jun;28(2):112-117. 10.7570/jomes.2019.28.2.112.

Association between Body Fat and Diabetic Peripheral Neuropathy in Middle-Aged Adults with Type 2 Diabetes Mellitus: A Preliminary Report

• Oh TJ
• Lee JE
• Choi SH
• Jang HC

• KMID: 2459823
• DOI: http://doi.org/10.7570/jomes.2019.28.2.112

Abstract

BACKGROUND
Previous epidemiologic studies showed that obesity increased the risk of diabetic peripheral neuropathy (DPN). However, there is very limited data about the impact of body fat measured by body composition analysis in DPN.
METHODS
Subjects with type 2 diabetes mellitus (T2DM) between 20 to 55 years old were enrolled. DPN was diagnosed using the Michigan Neuropathy Screening Instrument. Body composition was assessed by bio-impedance analysis, and the association between body composition and DPN was investigated.
RESULTS
Among 65 subjects, 44.6% were diagnosed with DPN. Subjects with DPN had higher body mass index and waist circumference than subjects without DPN. Body composition data showed that fat mass, fat percent, and visceral fat area were higher in subjects with DPN than in subjects without DPN. Furthermore, the presence of DPN was associated with waist circumference (odds ratio [OR], 1.151; 95% confidence interval [CI], 1.055-1.256; P=0.002), visceral fat area (OR, 1.026; 95% CI, 1.005-1.048; P=0.015), and insulin resistance (OR, 1.673; 95% CI, 1.091-2.565; P=0.018) after adjusting age, sex, diabetes duration, and smoking status.
CONCLUSION
Abdominal obesity was associated with DPN. Insulin resistance might mediate obesity and DPN in middle aged subjects with T2DM.

Keyword

Diabetic neuropathy; Obesity; Visceral fat; Insulin resistance

MeSH Terms

Adipose Tissue*
Adult*
Body Composition
Body Mass Index
Diabetes Mellitus, Type 2*
Diabetic Neuropathies
Epidemiologic Studies
Humans
Insulin Resistance
Intra-Abdominal Fat
Mass Screening
Michigan
Middle Aged
Obesity
Obesity, Abdominal
Peripheral Nervous System Diseases*
Smoke
Smoking
Waist Circumference
Smoke