J Korean Soc Radiol.  2019 Sep;80(5):963-968. 10.3348/jksr.2019.80.5.963.

The Effectiveness of Interventional Trans-Arterial Embolization to Control Active Bleeding Before Medical Treatment in Patients with Acquired Hemophilia Presenting as Retroperitoneal Hematoma and Hemothorax: A Case Report

Affiliations
  • 1Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. kdk7118@yuhs.ac

Abstract

The author report a case involving a 60-year-old man with acquired hemophilia who presented with sudden-onset left abdominal pain and exhibited retroperitoneal hematoma and hemothorax. In the long term, the patient is being successfully treated with recombinant activated coagulation factor VII. Before this, when the initial active bleeding was detected, successful interventional trans-arterial embolization of the lumbar arteries was performed for immediate hemostasis using N-butyl cyanoacrylate glue and microcoils. This report highlights the effectiveness of immediate interventional trans-arterial embolization in a case of active bleeding in a patient with acquired hemophilia.


MeSH Terms

Abdominal Pain
Adhesives
Arteries
Cyanoacrylates
Embolization, Therapeutic
Factor VII
Hematoma*
Hemophilia A*
Hemorrhage*
Hemostasis
Hemothorax*
Humans
Middle Aged
Retroperitoneal Space
Adhesives
Cyanoacrylates
Factor VII

Figure

  • Fig. 1 Interventional trans-arterial embolization to control active bleeding before medical treatment in patients with acquired hemophilia. Initial chest and abdominopelvic CT scan revealing right hemothorax (A) and extensive left psoas hemorrhagic muscular swelling, with adjacent retroperitoneal hematoma and bizarre, multifocal bleeding foci (B, arrows). Emergent endovascular embolization of the left lower lumbar arteries was performed successfully using N-butyl cyanoacrylate glue and microcoils. Similar to the initial CT scan, multifocal tiny bleeding foci were confirmed on angiography (C and D, arrows). At the latest follow-up abdominopelvic CT and chest CT scan 4 months after successful embolization, markedly decreased left retroperitoneal hematoma (E) and right hemothorax (F) with liquefaction were noted without evidence of active bleeding.


Reference

1. Lottenberg R, Kentro TB, Kitchens CS. Acquired hemophilia: a natural history study of 16 patients with factor VIII inhibitors receiving little or no therapy. Arch Intern Med. 1987; 147:1077–1081.
Article
2. Chan YC, Morales JP, Reidy JF, Taylor PR. Management of spontaneous and iatrogenic retroperitoneal haemorrhage: conservative management, endovascular intervention or open surgery? Int J Clin Pract. 2008; 62:1604–1613.
Article
3. Hoots WK. Emergency care issues in hemophilia. Treatment of Hemophilia. Montreal: World Federation of Hemophilia (WFH);2007. p. 43.
4. Dzielski T, Nowicka D, Pasz P, Wojciechowska J. Hemothorax and retroperitoneal hematoma with the secondary posthemorrhagic anemia as a complication of oral anticoagulant and non-steroidal anti-inflammatory drug therapy. Pol Merkur Lekarski. 2000; 8:335–336.
5. Fan WX, Deng ZX, Liu F, Liu RB, He L, Amrit B, et al. Spontaneous retroperitoneal hemorrhage after hemodialysis involving anticoagulant agents. J Zhejiang Univ Sci B. 2012; 13:408–412.
Article
6. Moskovitz B, Braner B, Engel A, Kleinhaus U, Levin DR. Multifocal bleeding due to anticoagulant therapy. Urol Int. 1988; 43:53–55.
Article
7. Fukushima T, Mikane T, Ono D, Oku S, Kobayashi H, Watanabe Y, et al. A case of acquired hemophilia A with massive hemothorax. J Anesth. 2012; 26:262–264.
Article
8. Franchini M, Gandini G, Di Paolantonio T, Mariani G. Acquired hemophilia A: a concise review. Am J Hematol. 2005; 80:55–63.
Article
9. Huth-Kühne A, Baudo F, Collins P, Ingerslev J, Kessler CM, Lévesque H, et al. International recommendations on the diagnosis and treatment of patients with acquired hemophilia A. Haematologica. 2009; 94:566–575.
Article
10. Jae HJ, Chung JW, Jung AY, Lee W, Park JH. Transcatheter arterial embolization of nonvariceal upper gastrointestinal bleeding with N-butyl cyanoacrylate. Korean J Radiol. 2007; 8:48–56.
Article
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