J Korean Diabetes.  2019 Sep;20(3):149-156. 10.4093/jkd.2019.20.3.149.

Injectable Therapy for Diabetes Mellitus: Glucagon-Like Peptide-1 Receptor Agonist

• Lee I
• Kang ES

• KMID: 2458964
• DOI: http://doi.org/10.4093/jkd.2019.20.3.149

Abstract

According to the American Diabetes Association (ADA) and the European Association for the Study of Diabetes guideline for treatment of diabetes, glucagon-like peptide-1 receptor agonist (GLP-1 RA) is recommended in diabetic patients with established atherosclerotic cardiovascular disease. This recommendation is based on the results of recent cardiovascular outcome trials of this kind of medications. GLP-1 RAs have a glucose lowering effect with weight loss and a lower incidence of hypoglycemia, and can improve cardiovascular outcomes such as three-point major cardiovascular events composed of death from cardiovascular causes, non-fatal myocardial infarction, and non-fatal stroke. Also, several GLP-1 RAs have beneficial effects on renal outcomes, mainly due to improvement in macroalbuminuria. In addition, high-dose liraglutide (3 mg/day subcutaneous injection) showed efficacy for reducing body weight. Therefore GLP-1 RA may be effective in patients with established cardiovascular disease, chronic kidney disease, and/or metabolic syndrome.

Keyword

Cardiovascular diseases; Diabetes mellitus; Glucagon-like peptide-1; Kidney diseases; Obesity

MeSH Terms

Body Weight
Cardiovascular Diseases
Diabetes Mellitus*
Glucagon-Like Peptide 1*
Glucagon-Like Peptide-1 Receptor*
Glucose
Humans
Hypoglycemia
Incidence
Kidney Diseases
Liraglutide
Myocardial Infarction
Obesity
Renal Insufficiency, Chronic
Stroke
Weight Loss
Glucagon-Like Peptide 1
Glucagon-Like Peptide-1 Receptor
Glucose
Liraglutide

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