Clin Exp Reprod Med.  2019 Sep;46(3):99-106. 10.5653/cerm.2019.00276.

Understanding the molecular mechanisms of bisphenol A action in spermatozoa

• Rahman MS
• Pang MG

• KMID: 2458496
• DOI: http://doi.org/10.5653/cerm.2019.00276

Abstract

Bisphenol A (BPA) is an endocrine-disrupting chemical that is capable of interfering with the normal function of the endocrine system in the body. Exposure to this chemical from BPA-containing materials and the environment is associated with deleterious health effects, including male reproductive abnormalities. A search of the literature demonstrated that BPA, as a toxicant, directly affects the cellular oxidative stress response machinery. Because of its hormone-like properties, it can also bind with specific receptors in target cells. Therefore, the tissue-specific effects of BPA mostly depend on its endocrine-disrupting capabilities and the expression of those particular receptors in target cells. Although studies have shown the possible mechanisms of BPA action in various cell types, a clear consensus has yet to be established. In this review, we summarize the mechanisms of BPA action in spermatozoa by compiling existing information in the literature.

Keyword

Bisphenol A; Endocrine disruptors; Mechanism of action; Oxidative stress; Spermatozoa

MeSH Terms

Consensus
Endocrine Disruptors
Endocrine System
Humans
Male
Oxidative Stress
Spermatozoa*
Endocrine Disruptors