Kidney Res Clin Pract.
2019 Sep;38(3):365-372. 10.23876/j.krcp.18.0155.
Perirenal fat thickness is associated with metabolic risk factors in patients with chronic kidney disease
- Affiliations
-
- 1Consorci Sanitari del Garraf, Servicio de NefrologÃa, Barcelona, Spain. luisgerardodg@hotmail.com
- 2Advanced Unit of Renal Sonographic Diagnostics, Puerto Ordaz Clinic, Puerto Ordaz City, Venezuela.
- 3Department of Physiological Sciences, Universidad de Oriente, BolÃvar, Venezuela.
- 4Universidad Simon BolÃvar Facultad de Ciencias de la Salud, Barranquilla, Colombia.
- 5Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
- KMID: 2457728
- DOI: http://doi.org/10.23876/j.krcp.18.0155
Abstract
- BACKGROUND
Adipose tissue accumulation in specific body compartments has been associated with diabetes, hypertension and dyslipidemia. Perirenal fat (PRF) may lead to have direct lipotoxic effects on renal function and intrarenal hydrostatic pressure. This study was undertaken to explore the association of PRF with cardiovascular risk factors and different stages of chronic kidney disease (CKD).
METHODS
We studied 103 patients with CKD of different stages (1 to 5). PRF was measured by B-mode renal ultrasonography in the distal third between the cortex and the hepatic border and/or spleen.
RESULTS
The PRF thickness was greater in CKD patients with impaired fasting glucose than in those with normal glucose levels (1.10 ± 0.40 cm vs. 0.85 ± 0.39 cm, P < 0.01). Patients in CKD stages 4 and 5 (glomerular filtration rate [GFR] < 30 mL/min/1.73 m²) had the highest PRF thickness. Serum triglyceride levels correlated positively with the PRF thickness; the PRF thickness was greater in patients with triglyceride levels ≥ 150 mg/dL (1.09 ± 0.40 cm vs. 0.86 ± 0.36 cm, P < 0.01). In patients with a GFR < 60 mL/min/1.73 m², uric acid levels correlated positively with the PRF thickness (P < 0.05).
CONCLUSION
In CKD patients, the PRF thickness correlated significantly with metabolic risk factors that could affect kidney function.
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