Korean J Blood Transfus.
2019 Apr;30(1):65-70. 10.17945/kjbt.2019.30.1.65.
Weak D type 33 Found in a Patient with a Weak D Phenotype: The First Case in Korea
- Affiliations
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- 1Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Korea. duck.cho@skku.edu
- 2Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
- 3Department of Laboratory Medicine, Chosun University College of Medicine, Gwangju, Korea. creatgeon@chosun.ac.kr
- KMID: 2457204
- DOI: http://doi.org/10.17945/kjbt.2019.30.1.65
Abstract
- RHD genotyping is a useful adjunct to serologic testing. Although the use of RHD genotyping in the detection of Asia type DEL in serological D negative Koreans is gradually increasing, it is rarely requested for patients with a known weak D phenotype. This paper reports the first Korean case of a 52-year-old female patient with serologic weak D phenotype and weak D type 33 (c.520G>A at exon 4 of RHD) identified by RHD exon 1 to 10 sequencing. In silico analysis predicted that the RHD c.520G>A (V174M) results in a serologic weak D phenotype.
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