J Korean Med Sci.  2019 Aug;34(32):e204. 10.3346/jkms.2019.34.e204.

Association of Vitamin D with Inflammatory Bowel Disease Activity in Pediatric Patients

• Kim S
• Kang Y
• Park S
• Koh H
• Kim S

• KMID: 2455491
• DOI: http://doi.org/10.3346/jkms.2019.34.e204

Abstract

BACKGROUND
It has been known that vitamin D level (serum 25[OH]D) has correlation with inflammatory bowel disease (IBD). The purpose of this study is to investigate changes of serum 25[OH]D in pediatric IBD patients according to the disease activity.
METHODS
A total of 96 children and adolescent with IBD were enrolled in this retrospective study. Serologic inflammatory markers and clinical disease activity scores of the patients were collected, and their correlations with serum 25[OH]D were analyzed. Seasonal variations of serum 25[OH]D were also investigated both in active disease state and remission state.
RESULTS
Of the 96 patients, 41 (43%) were women and patients with a vitamin D deficiency (< 20 ng/mL) at diagnosis were 77 (80.2%). There was no significant difference between Crohn's disease and ulcerative colitis for serum 25[OH]D. Serum 25[OH]D was higher in remission group than in active disease group (12.4 [8.8-29] ng/mL vs. 17.9 [12.3-34.4] ng/mL; P < 0.001) and the difference was more significant than other micronutrients. There was no significant difference in serum 25[OH]D concentration between patients with ileal involvement and patients without ileal involvement. There were seasonal variations in the active phase, but there was no significant difference by season in the remission phase.
CONCLUSION
Serum 25[OH]D is inversely correlated with disease activity in IBD. Monitoring and supplementation is required especially for active disease status and in winter and spring season.

Keyword

Vitamin D; Inflammatory Bowel Disease; Crohn's Disease; Ulcerative Colitis; Disease Activity; Pediatric

MeSH Terms

Adolescent
Child
Colitis, Ulcerative
Crohn Disease
Diagnosis
Female
Humans
Inflammatory Bowel Diseases*
Micronutrients
Retrospective Studies
Seasons
Vitamin D Deficiency
Vitamin D*
Vitamins*
Micronutrients
Vitamin D
Vitamins