Intest Res.  2019 Jul;17(3):413-418. 10.5217/ir.2018.00156.

Clinical comparison of low-volume agents (oral sulfate solution and sodium picosulfate with magnesium citrate) for bowel preparation: the EASE study

• Kim J
• Kim HG
• Kim KO
• Kim HW
• Park J
• Byeon JS
• Hwang SW
• Shin HD
• Shin JE
• Yang HJ
• Lee HS
• Jung Y
• Cho YS
• Joo YE
• Myung DS
• Huh KC
• Ahn EM

• KMID: 2454750
• DOI: http://doi.org/10.5217/ir.2018.00156

Abstract

BACKGROUND/AIMS
This study compared the efficacy, compliance, and safety of bowel preparation between sodium picosulfate with magnesium citrate (SPMC) and oral sulfate solution (OSS).
METHODS
A prospective randomized multicenter study was performed. Split preparation methods were performed in both groups; the SPMC group, 2 sachets on the day before, and 1 sachet on the day of the procedure, the OSS group, half of the OSS with 1 L of water on both the day before and the day of the procedure. The adenoma detection rate (ADR), adequacy of bowel preparation using the Boston Bowel Preparation Scale (BBPS) score, patient satisfaction on a visual analog scale (VAS), and safety were compared between the 2 groups.
RESULTS
This study analyzed 229 patients (121 in the SPMC group and 108 in the OSS group). ADR showed no differences between 2 groups (51.7% vs. 41.7%, P>0.05). The mean total BBPS score (7.95 vs. 8.11, P>0.05) and adequate bowel preparation rate (94.9% vs. 96.3%, P>0.05) were similar between the 2 groups. The mean VAS score for taste (7.62 vs. 6.87, P=0.006) was significantly higher in the SPMC group than in the OSS group. There were no significant differences in any other safety variables between the 2 groups except nausea symptom (36.1% vs. 20.3%, P=0.008).
CONCLUSIONS
Bowel preparation for colonoscopy using low volume OSS and SPMC yielded similar ADRs and levels of efficacy. SPMC had higher levels of satisfaction for taste and feeling than did OSS.

Keyword

Colonoscopy; Bowel preparation; Oral sulfate solution; Sodium picosulfate with magnesium citrate

MeSH Terms

Adenoma
Citric Acid
Colonoscopy
Compliance
Humans
Magnesium*
Nausea
Patient Satisfaction
Prospective Studies
Sodium*
Visual Analog Scale
Water
Citric Acid
Magnesium
Sodium
Water

Figure

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  Fig. 1. Characteristics of the study participants. IRB, institutional review board; OSS, oral sulfate solution; ITT, intention-to-treat; PP, per protocol; SPMC, sodium picosulfate with magnesium citrate.

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