Cancer Res Treat.
2019 Jul;51(3):1033-1040. 10.4143/crt.2018.447.
Genetic Risk Score, Combined Lifestyle Factors and Risk of Colorectal Cancer
- Affiliations
-
- 1Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea. jskim@ncc.re.kr
- 2Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Goyang, Korea.
- 3Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
- KMID: 2454295
- DOI: http://doi.org/10.4143/crt.2018.447
Abstract
- PURPOSE
Both genetic and lifestyle factors contribute to the risk of colorectal cancer, but each individual factor has a limited effect. Therefore, we investigated the association between colorectal cancer and the combined effects of genetic factors or/and lifestyle risk factors.
MATERIALS AND METHODS
In a case-control study of 632 colorectal cancer patients and 1,295 healthy controls, we quantified the genetic risk score for colorectal cancer using 13 polymorphisms. Furthermore, we determined a combined lifestyle risk score including obesity, physical activity, smoking, alcohol consumption, and dietary inflammatory index. The associations between colorectal cancer and risk score using these factors were examined using a logistic regression model.
RESULTS
Higher genetic risk scores were associated with an increased risk of colorectal cancer (odds ratio [OR], 2.57; 95% confidence interval [CI], 1.89 to 3.49 for the highest tertile vs. lowest tertile). Among the modifiable factors, previous body mass index, physical inactivity, heavy alcohol consumption, and a high inflammatory diet were associated with an increased risk of colorectal cancer. A higher lifestyle risk score was associated with an increased risk of colorectal cancer (OR, 5.82; 95% CI, 4.02 to 8.44 for the highest tertile vs. lowest tertile). This association was similar in each genetic risk category.
CONCLUSION
Adherence to a healthy lifestyle is associated with a substantially reduced risk of colorectal cancer regardless of individuals' genetic risk.
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