Asia Pac Allergy.  2019 Jul;9(3):e28. 10.5415/apallergy.2019.9.e28.

Signals from the various immune cells in promoting food allergy-induced eosinophilic esophagitis like disease

• Lianto P
• Zhang Y
• Che H

• KMID: 2454162
• DOI: http://doi.org/10.5415/apallergy.2019.9.e28

Abstract

Eosinophilic esophagitis (EoE) is a recently recognized esophageal inflammatory disease with clinical manifestations arising from esophageal dysfunction. The etiology of EoE is currently being clarified and food allergy is evolving as the central cornerstone of EoE disease pathogenesis. Given the large number of eosinophils in the esophagus of people with EoE verified by data from murine models EoE is widely considered as the hallmark T-helper type 2 (Th2) disease of the esophagus. It is also known that some eosinophilic inflammation is controlled by other subsets of T cells such as Th9 or Th17 and control is also exerted by type 2 innate lymphoid cells acting together with basophils. In this paper we review results from molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and present in-depth molecular understanding of EoE.

Keyword

Eosinophilic esophagitis; Food allergy; Pathogenesis; Elimination diet; Therapy

MeSH Terms

Animals
Basophils
Cytokines
Eosinophilic Esophagitis*
Eosinophils*
Esophagus
Food Hypersensitivity
Humans
Inflammation
Lymphocytes
Mice
T-Lymphocytes
Cytokines