Korean J Parasitol.  2019 Jun;57(3):249-256. 10.3347/kjp.2019.57.3.249.

Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection

Affiliations
  • 1Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan and National Yang-Ming University, Taipei, Taiwan. hctsai1011@yahoo.com.tw
  • 2Department of Parasitology and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Abstract

Steroids are commonly used in patients with eosinophilic meningitis caused by A. cantonensis infections. The mechanism steroids act on eosinophilic meningitis remains unclear. In this mouse experiments, expressions of 14-3-3 isoform β and γ proteins significantly increased in the CSF 2-3 weeks after the infection, but not increasedin the dexamethasone-treated group. Expression of 14-3-3 β, γ, ɛ, and θ isoforms increased in brain meninges over the 3-week period after infection and decreased due to dexamethasone treatment. In conclusion, administration of dexamethasone in mice with eosinophilic meningitis decreased expressions of 14-3-3 isoform proteins in the CSF and in brain meninges.

Keyword

Angiostrongylus cantonensis; dexamethasone; eosinophile; meningitis; 14-3-3 isoform

MeSH Terms

Angiostrongylus cantonensis*
Angiostrongylus*
Animals
Brain
Dexamethasone*
Eosinophils*
Humans
Meninges
Meningitis*
Mice*
Protein Isoforms
Steroids
Dexamethasone
Protein Isoforms
Steroids
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