Soonchunhyang Med Sci.  2019 Jun;25(1):20-27. 10.0000/sms.2019.25.1.20.

Oxycodone versus Fentanyl for Intravenous Patient-Controlled Analgesia after Laparoscopic Gynecologic Surgery

• Kim NS
• Kim JE

• KMID: 2452791
• DOI: http://doi.org/10.0000/sms.2019.25.1.20

Abstract

OBJECTIVE
Oxycodone, a semi-synthetic thebaine derivative opioid, is commonly used for treating moderate to severe pain. The aim of this study was to compare the efficacy and side effects of oxycodone and fentanyl used for treating postoperative pain with intravenous patient-controlled analgesia (IV-PCA) after laparoscopic gynecologic surgery.
METHODS
A total of 122 patients were randomized to receive postoperative pain treatment with either oxycodone (n=62, group O) or fentanyl (n=60, group F). Patients received 7.5 mg oxycodone and 150 mcg fentanyl with ketorolac 30 mg at the end of anesthesia, and then continued with IV-PCA (conversion dose ratio, 50:1) for 48 hours postoperatively. A blinded observer assessed postoperative pain based on a numerical rating scale, postoperative nausea and vomiting and other side effects, infused PCA dose, patient satisfaction, and sedation level.
RESULTS
No significant differences were observed in patient satisfaction according to the analgesic used during the 48 hours postoperative period.
CONCLUSION
Oxycodone showed similar efficacy for pain relief compared to fentanyl when used at a conversion dose ratio of 50:1. Therefore, oxycodone may be useful as an alternative to fentanyl for IV-PCA after laparoscopic gynecologic surgery.

Keyword

Fentanyl; Oxycodone; Postoperative pain

MeSH Terms

Analgesia, Patient-Controlled*
Anesthesia
Female
Fentanyl*
Gynecologic Surgical Procedures*
Humans
Ketorolac
Oxycodone*
Pain, Postoperative
Passive Cutaneous Anaphylaxis
Patient Satisfaction
Postoperative Nausea and Vomiting
Postoperative Period
Thebaine
Fentanyl
Ketorolac
Oxycodone
Thebaine