Korean J Anesthesiol.  2015 Jun;68(3):261-266. 10.4097/kjae.2015.68.3.261.

A comparison of oxycodone and fentanyl in intravenous patient-controlled analgesia after laparoscopic hysterectomy

• Kim NS
• Kang KS
• Yoo SH
• Chung JH
• Chung JW
• Seo Y
• Chung HS
• Jeon HR
• Gong HY
• Lee HY
• Mun ST

• KMID: 2148691
• DOI: http://doi.org/10.4097/kjae.2015.68.3.261

Abstract

BACKGROUND
We planned to compare the effect of intravenous oxycodone and fentanyl on post-operative pain after laparoscopic hysterectomy.
METHODS
We examined 60 patients were randomized to postoperative pain treatment with either oxycodone (n = 30, Group O) or fentanyl (n = 30, Group F). The patients received 10 mg oxycodone/100 microg fentanyl with ketorolac 30 mg before the end of anesthesia and then continued with patient-controlled analgesia for 48 h postoperatively.
RESULTS
The accumulated oxycodone consumption was less than fentanyl during 8, 24 and 48 h postoperatively. Numeric rating score of Group O showed significantly lower than that of Group F during 30 min, 2, 4, 8 and 24 h postoperatively. The incidences of adverse reactions were similar in the two groups, though the incidence of nausea was higher in the Group O during the 24 and 48 h postoperative period.
CONCLUSIONS
Oxycodone IV-PCA was more advantageous than fentanyl IV-PCA for laparoscopic hysterectomy in view of accumulated oxycodone consumption, pain control and cost beneficial effect. However, patient satisfaction was not good in the group O compared to group F.

Keyword

Fentanyl; Oxycodone; Postoperative pain

MeSH Terms

Analgesia, Patient-Controlled*
Anesthesia
Fentanyl*
Humans
Hysterectomy*
Incidence
Ketorolac
Nausea
Oxycodone*
Pain, Postoperative
Patient Satisfaction
Postoperative Period
Fentanyl
Ketorolac
Oxycodone