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A new therapeutic option for postoperative pain management with oxycodone HCI injection

Choi BM

Fentanyl is the most commonly used opioid analgesic in intravenous patient-controlled analgesia (IV PCA) in Korea. IV oxycodone was approved for postoperative IV PCA by the Ministry of Food and...
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Oxycodone: A New Therapeutic Option in Postoperative Pain Management

Choi BM

Oxycodone is a semi-synthetic opioid synthesized from poppy-derived thebaine. It is a narcotic analgesic generally indicated for relief of moderate to severe pain. Although developed in an attempt to improve...
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Comparison of oxycodone and fentanyl for postoperative patient-controlled analgesia after orthopedic surgery

Lee DW, An J, Kim E, Lee JH, Kim H, Son JC

BACKGROUND: Oxycodone is widely used as bolus or patient-controlled analgesia (PCA) for control of postoperative pain. The aim of this study was to assess the efficacy and side effects of...
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Comparison of the analgesic efficacy of oxycodone and fentanyl after dental surgery

Lee JE, Park CR, Park SS

BACKGROUND: Oxycodone is a strong m-opioid receptor agonist and has a longer duration of analgesic effect than fentanyl. We compared the use of an intravenous (IV) bolus of oxycodone and...
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Oxycodone versus Fentanyl for Intravenous Patient-Controlled Analgesia after Laparoscopic Gynecologic Surgery

Kim NS, Kim JE

OBJECTIVE: Oxycodone, a semi-synthetic thebaine derivative opioid, is commonly used for treating moderate to severe pain. The aim of this study was to compare the efficacy and side effects of...
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Comparison of oxycodone and fentanyl for postoperative patient-controlled analgesia after laparoscopic gynecological surgery

Park JH, Lee C, Shin Y, An JH, Ban JS, Lee JH

BACKGROUND: Opioids are widely used in boluses and patient-controlled analgesia (PCA) for postoperative pain control. In this study, we compared the effects of oxycodone and fentanyl on postoperative pain in...
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Oxycodone vs. fentanyl in the treatment of early post-operative pain after total knee replacement: randomized controlled trial

Yang SA, Kim KS, Kang HY

BACKGROUND: Total knee replacement is often accompanied by severe post-operative pain. Oxycodone has sufficient analgesic effects and somewhat greater, but tolerable side effects compared to fentanyl. However, most studies on...
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A comparison of oxycodone and fentanyl in the management of early postoperative pain and for patient-controlled analgesia after total abdominal hysterectomy

Seo DK, Lee CJ, Kim JS

BACKGROUND: Although oxycodone has been known to be superior to other opioids in postoperative care, few studies have compared its analgesic potency with that of fentanyl. We therefore examined these...
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Colorectal Transit and Volume During Treatment With Prolonged-release Oxycodone/Naloxone Versus Oxycodone Plus Macrogol 3350

Poulsen JL, Mark EB, Brock C, Frøkjær , Krogh K, Drewes AM

  • KMID: 2417279
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):119-127.
  • doi: 10.5056/jnm17058
BACKGROUND/AIMS: Opioid-induced constipation (OIC) is the most common gastrointestinal (GI) side effect to opioid treatment. Opioid receptor antagonists against OIC have been introduced, but their efficacy has not been directly...
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A comparison of oxycodone and fentanyl in intravenous patient-controlled analgesia after laparoscopic hysterectomy

Kim NS, Kang KS, Yoo SH, Chung JH, Chung JW, Seo Y, Chung HS, Jeon HR, Gong HY, Lee HY, Mun ST

BACKGROUND: We planned to compare the effect of intravenous oxycodone and fentanyl on post-operative pain after laparoscopic hysterectomy. METHODS: We examined 60 patients were randomized to postoperative pain treatment with either...
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Opioid Withdrawal Symptoms after Conversion to Oral Oxycodone/Naloxone in Advanced Cancer Patients Receiving Strong Opioids

Kim JH, Song H, Lee GW, Kang JH

PURPOSE: Oral naloxone is combined with oxycodone to alleviate or prevent opioid-induced constipation in cancer pain patients. However, there is still concern that oral naloxone may precipitate opioid withdrawal symptoms...
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Comparison of Ramosetron Dose in Patients with Postoperative Nausea and Vomiting Who Received Oxycodone-Based Intravenous Patient-Controlled Analgesia after Undergoing Gynecological Laparoscopic Surgery

Gong HY

OBJECTIVE: Pain that occurs following gynecological laparoscopic surgery is a main cause for prolonged hospitalization. As a solution, various intravenous patient-controlled analgesia (IV PCA) systems have been used to control...
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A Case of Acute Toxic Encephalopathy due to an Oxycodone Overdose

Kim SP, Lee DH, Yoon DH, Kim SJ, Cho SH, Cho NS, Kim BC

  • KMID: 2332542
  • J Korean Soc Emerg Med.
  • 2008 Oct;19(5):598-601.
Acute encephalopathies can be defined as an acute central nervous system (CNS) insult, due to an underlying pathology. The clinical symptoms almost always include an acute state of confusion and...
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Effects of Naloxegol on Gastrointestinal Transit and Colonic Fecal Volume in Healthy Participants Receiving Oxycodone

Olesen AE, Grønlund , Mark EB, Krogh K, Frøkjær , Drewes AM

  • KMID: 2460489
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):602-610.
  • doi: 10.5056/jnm18079
BACKGROUND/AIMS: Opioids cause gastrointestinal (GI) dysmotility, decrease gut secretion, and affect gut sphincters. Symptoms of opioid-induced bowel dysfunction may be alleviated by peripherally acting opioid antagonists like naloxegol, but detailed...
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The Impact of Opioid Treatment on Regional Gastrointestinal Transit

Poulsen JL, Nilsson M, Brock C, Sandberg T, Krogh K, Drewes AM

  • KMID: 2203582
  • J Neurogastroenterol Motil.
  • 2016 Apr;22(2):282-291.
  • doi: 10.5056/jnm15175
BACKGROUND/AIMS: To employ an experimental model of opioid-induced bowel dysfunction in healthy human volunteers, and evaluate the impact of opioid treatment compared to placebo on gastrointestinal (GI) symptoms and motility...
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An Analysis on the Effect of Patient-controlled Analgesia Performed by Orthopaedic Department or Postoperative Pain Control after Shoulder and Elbow Surgery

Yum JK, Kim JH, Boo KH, Ahn SH

BACKGROUND: We investigated the effectiveness of pain management and the adverse events of intravenous (IV) patient-controlled analgesia (PCA) after orthopedic surgery. METHODS: From September 2014 and August 2015, we performed a...
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A Case of Patient with Opioid-Induced Adrenocortical Insufficiency and Hypogonadism

Kim HJ, Kim CS, Park JS, Park J, Kang ES, Ahn CW, Cha BS, Lim SK, Kim KR, Lee HC

Opioids are known to decrease plasma cortisol and testosterone level in human and other mammals. Nowadays, opioid use is exponentially increasing, but little is known about its side effects. With...
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Breakthrough Cancer Pain

Seo MS, Shim JY

Breakthrough cancer pain is a transient exacerbation of pain that occurs despite relatively well controlled background pain with around-the-clock analgesia. It is highly prevalent in patients with cancer pain, with...
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Comparison of patient-controlled epidural analgesia with patient-controlled intravenous analgesia for laparoscopic radical prostatectomy

Hwang BY, Kwon JY, Jeon SE, Kim ES, Kim HJ, Lee HJ, An J

BACKGROUND: Patient-controlled epidural analgesia (PCEA) is known to provide good postoperative analgesia in many types of surgery including laparoscopic surgery. However, no study has compared PCEA with patient-controlled intravascular analgesia...
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Physician's Attitude toward Treating Breakthrough Cancer Pain in Korea

Seo MS, Shim JY, Choi YS, Kim DY, Hwang IG, Baek SK, Shin JY, Lee J, Lee CG

PURPOSE: Adequate control of breakthrough pain is essential for patients with cancer. Managing breakthrough pain mainly depends on understanding the concept of breakthrough pain and the proper usage of rescue...
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