Nat Prod Sci.  2019 Jun;25(2):92-102. 10.20307/nps.2019.25.2.92.

The Potential of Centella asiatica (Linn.) Urban as an Anti-Microbial and Immunomodulator Agent: A Review

• Harun NH
• Septama AW
• Wan Ahmad
• Suppian R

• KMID: 2452777
• DOI: http://doi.org/10.20307/nps.2019.25.2.92

Abstract

Centella asiatica (Linn.) Urban (Umbelliferae) which is also known as "˜pegaga' is highly consumed and eaten raw as "˜ulam' in Malaysia. C. asiatica is used in traditional medicines to treat various health conditions such as rheumatism, inflammation, syphilis, skin diseases and diarrhoea. Various reports exhibited that the crude extracts and isolated bioactive compounds of C. asiatica possessed a broad range of pharmacological activities such as anti-oxidant, anti-diabetic, anti-tumor, wound healing, anti-microbial, anti-inflammatory, immunomodulatory, hepatoprotective and memory enhancing properties. The pharmacological validation on anti-microbial and immunomodulatory of C. asiatica is very limited and several existence review papers related for this plant had not been focused for both activities. This review therefore attempts to combine the existing literature to offer immense scope for researchers engaged in validation of the traditional claims and bioactivities of this plant related with anti-microbial and immunomodulatory potential.

Keyword

Anti-microbial; Centella asiatica (Linn.) Urban; immunomodulatory; pegaga

MeSH Terms

Centella*
Complex Mixtures
Inflammation
Malaysia
Memory
Plants
Rheumatic Diseases
Syphilis, Cutaneous
Wound Healing
Complex Mixtures

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