Korean J Thorac Cardiovasc Surg.  2019 Feb;52(1):44-46. 10.5090/kjtcs.2019.52.1.44.

Chylous Manifestations and Management of Gorham-Stout Syndrome

Affiliations
  • 1Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine. choishn@gmail.com
  • 2Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine.

Abstract

Gorham-Stout disease (GSD) was first described by Gorham and colleagues in 1954, but its precise mechanism and cause remain to be elucidated. In this condition, voluminous and potentially fatal chylous effusions into the thorax can occur. Herein, we describe a case of GSD in which the patient presented with massive pleural effusions and mottled osteolytic bone lesions. We performed multiple operations, including thoracic duct ligation using video-assisted thoracoscopic surgery and thoracotomic decortication, but these procedures did not succeed in preventing recurrent pleural effusion and chest wall lymphedema. After administering sirolimus (0.8 mg/m2, twice a day) and propranolol (40 mg, twice a day), the process of GSD in this patient has been controlled for more than 2 years.

Keyword

Gorham-Stout disease; Pleural effusion; Sirolimus; Chylothorax

MeSH Terms

Chylothorax
Humans
Ligation
Lymphedema
Osteolysis, Essential
Pleural Effusion
Propranolol
Sirolimus
Thoracic Duct
Thoracic Surgery, Video-Assisted
Thoracic Wall
Thorax
Propranolol
Sirolimus
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