Korean J Pediatr.  2019 Apr;62(4):126-130. 10.3345/kjp.2018.07010.

The association between preeclampsia and autism spectrum disorders among children: a meta-analysis

• Jenabi E
• Karami M
• Khazaei S
• Bashirian

• KMID: 2451949
• DOI: http://doi.org/10.3345/kjp.2018.07010

Abstract

PURPOSE
In this meta-analysis, relevant case-control and cohort studies were pooled to evaluate the association between preeclampsia and the risk of autism spectrum disorders (ASDs) in children.
METHODS
A search for relevant studies in major databases, including Web of Science, PubMed, and Scopus, was performed up to May 2018. The odds ratios (ORs) or rate ratios (RRs) with 95% confidence intervals (CIs) were extracted from eligible studies to determine the association among studies.
RESULTS
The pooled estimates of ORs and RRs indicated a significant association between preeclampsia and ASD [(OR, 1.36; 95% CI, 1.12-1.60) and (RR, 1.30; 95% CI, 1.20-1.41)].
CONCLUSIONS
Despite existing controversy, our findings indicated that preeclampsia was associated with an increased risk of ASD among children.

Keyword

Autism spectrum disorder; Autism; Preeclampsia; Pregnancy

MeSH Terms

Autism Spectrum Disorder*
Autistic Disorder*
Case-Control Studies
Child*
Cohort Studies
Humans
Odds Ratio
Pre-Eclampsia*
Pregnancy