Clin Exp Pediatr.  2021 Jun;64(6):286-292. 10.3345/cep.2020.00864.

Association between pesticide and polychlorinated biphenyl exposure during pregnancy and autism spectrum disorder among children: a meta-analysis

• Mehri F
• Bashirian S
• khazaei S
• Jenabi E

• KMID: 2516275
• DOI: http://doi.org/10.3345/cep.2020.00864

Abstract

Background
The effect of exposure to environmental factors on autism spectrum disorders (ASD), especially during pregnancy, is unclear. Purpose: This meta-analysis investigated the association between exposure to pesticides and polychlorinated biphenyls (PCBs) during pregnancy and ASD risk among children.
Methods
We searched Scopus, PubMed, Web of Science, and ProQuest for articles published through September 2019. Random-effects models were used to examine the association among studies using pooled odds ratios (ORs) and their 95% confidence intervals (CI). I2 tests were used to measure interstudy heterogeneity.
Results
The pooled OR indicated a significant association between PCB and pesticide exposure during pregnancy and ASD risk among children (OR, 1.80; 95% CI, 1.26–2.34; and OR, 1.20; 95% CI, 1.02–1.39), respectively.
Conclusion
Findings of the present study indicate that exposure to pesticides and PCBs during pregnancy may affect the risk of ASD among children.

Keyword

Autism spectrum disorders; Autism; Metaanalysis; Polychlorinated biphenyls; Pesticides