Korean J Pediatr.  2019 Nov;62(11):405-409. 10.3345/kjp.2019.00668.

Evaluation of drug interventions for the treatment of sleep disorders in children with autism spectrum disorders: a systematic review

Affiliations
  • 1Pediatric Developmental Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
  • 2Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran. s.ataei@umsha.ac.ir
  • 3Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Abstract

A structured review study of drug interventions on sleep disorders in patients with autism spectrum disorders (ASD) has not been published to date. This systematic review aimed to investigate drug interventions for the treatment of sleep disorders in children with ASD. The Web of Science, PubMed, and Scopus databases were searched until March 2019. Study quality was assessed using the Delphi checklist. Due to the heterogeneity of the findings, a meta-analysis was not possible. Drug interventions for the treatment of sleep disorders in patients with ASD included melatonin, atomoxetine, and risperidone. Atomoxetine had no effect on sleep disorders in patients with ASD. A total of 10 studies were reviewed. Melatonin appears to be useful for the treatment of sleep problems in patients with ASD, but further studies are needed to determine the effects of other drugs.

Keyword

Drug; Sleep disorders; Autism spectrum disorders; Meta-analysis

MeSH Terms

Atomoxetine Hydrochloride
Autism Spectrum Disorder*
Autistic Disorder*
Checklist
Child*
Humans
Melatonin
Population Characteristics
Risperidone
Sleep Wake Disorders*
Atomoxetine Hydrochloride
Melatonin
Risperidone
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