J Korean Med Sci.  2019 Jul;34(27):e185. 10.3346/jkms.2019.34.e185.

The Effect of Mycophenolate Mofetil on Non-Renal Manifestations in Systemic Lupus Erythematosus: Results from Korean Lupus Network Registry

Affiliations
  • 1Division of Rheumatology, Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. kimsk714@cu.ac.kr
  • 2Department of Medical Statistics, Catholic University of Daegu School of Medicine, Daegu, Korea.
  • 3Department of Rheumatology, Chonnam National University Medical School, Gwangju, Korea.

Abstract

BACKGROUND
The objective of this study was to identify the effects of mycophenolate mofetil (MMF) on non-renal manifestations in systemic lupus erythematosus (SLE).
METHODS
The study population comprised 439 SLE patients from the Korean Lupus Network registry who were followed up annually and completed the baseline survey and two follow-up visits from 2014 to 2018. Disease activity, laboratory markers, and clinical manifestations including mucocutaneous lesions, arthritis, serositis, neurological disorders, and hematologic/immunologic abnormalities were assessed. All variables by group (MMF and non-MMF) effects with time (baseline, 1st follow-up, and 2nd follow-up) were analyzed by generalized estimation equation.
RESULTS
Seventy-two patients were treated with MMF. There was significant difference in frequencies of malar rash, arthritis, renal disorder, and hematologic disorder between MMF and non-MMF groups in total SLE patients. In subgroup analysis of hematologic abnormalities in total patients, frequency of leukopenia was significantly different between the two groups during follow-up (P = 0.001), but frequencies of hemolytic anemia, lymphopenia, and thrombocytopenia were not. In addition, frequencies of leukopenia in patients without lupus nephritis were significantly decreased in MMF group compared to non-MMF group (P = 0.012).
CONCLUSION
This study showed that MMF might be a beneficial treatment for hematologic abnormalities, especially leukopenia, in SLE.

Keyword

Systemic Lupus Erythematosus; Mycophenolate Mofetil; Non-Renal Manifestations

MeSH Terms

Anemia, Hemolytic
Arthritis
Biomarkers
Exanthema
Follow-Up Studies
Humans
Leukopenia
Lupus Erythematosus, Systemic*
Lupus Nephritis
Lymphopenia
Nervous System Diseases
Serositis
Surveys and Questionnaires
Thrombocytopenia
Biomarkers
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