Korean J Intern Med.  2011 Dec;26(4):470-473. 10.3904/kjim.2011.26.4.470.

A Case of Minimal Change Disease Treated Successfully with Mycophenolate Mofetil in a Patient with Systemic Lupus Erythematosus

• Hong YH
• Yun DY
• Jung YW
• Oh MJ
• Kim HJ
• Lee CK

• KMID: 1729253
• DOI: http://doi.org/10.3904/kjim.2011.26.4.470

Abstract

The World Health Organization classifies lupus nephritis as class I to V or VI. However, a few cases of minimal change glomerulopathy have been reported in association with systemic lupus erythematosus (SLE). Mycophenolate mofetil has been shown to be effective for treatment of minimal change disease and lupus nephritis. A 24-year-old woman diagnosed with SLE five years prior to presentation complained of a mild generalized edema. The urinalysis showed microscopic hematuria and proteinuria. The assessed amount of total proteinuria was 1,618 mg/24 hours. A renal biopsy demonstrated diffuse fusion of the foot processes of podocytes on electron microscopy. Mycophenolate mofetil was started in addition to the maintenance medications of prednisolone 10 mg/day and hydroxychloroquine 400 mg/day. After six months of treatment, the microscopic hematuria and proteinuria resolved, and the total urine protein decreased to 100 mg/24 hours.

Keyword

Nephrosis, lipoid; Lupus erythematosus, systemic; Mycophenolate mofetil

MeSH Terms

Antirheumatic Agents/therapeutic use
Female
Glucocorticoids/therapeutic use
Humans
Hydroxychloroquine/therapeutic use
Immunosuppressive Agents/*therapeutic use
Lupus Erythematosus, Systemic/complications/*pathology
Mycophenolic Acid/*analogs & derivatives/therapeutic use
Nephrosis, Lipoid/*drug therapy/etiology/pathology
Prednisone/therapeutic use
Young Adult