Electrolyte Blood Press.  2019 Jun;17(1):21-24. 10.5049/EBP.2019.17.1.21.

Severe Hypocalcemia in a Patient with Tuberous Sclerosis Complex

Affiliations
  • 1Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. mednep@snubh.org
  • 2Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Abstract

Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder affecting multiple organs, including the brain, skin, lung, and kidney. Among the multiple comorbidities in TSC, bone mineral disturbances remain relatively unrecognized, and only a few studies have reported alteration in calcium homeostasis. Hypocalcemia is a serious medical condition in patients with TSC who are at high risk for seizures. Therefore, hypocalcemia should be thoroughly evaluated by obtaining a history of associated medication use and measuring vitamin D levels. Here, we report the case of a patient with TSC who presented with severe hypocalcemia which may have been related to a history of anticonvulsant use and a recent decline in kidney function, and was successfully treated with calcium and vitamin D replacement.

Keyword

Hypocalcemia; Vitamin D deficiency; Tuberous sclerosis complex

MeSH Terms

Brain
Calcium
Comorbidity
Homeostasis
Humans
Hypocalcemia*
Kidney
Lung
Miners
Seizures
Skin
Tuberous Sclerosis*
Vitamin D
Vitamin D Deficiency
Calcium
Vitamin D

Figure

  • Fig. 1 Abdominal and chest computed tomography showing bilateral multiple numerous renal AML and multifocal micronodular pneumocyte hyperplasia associated with TSC.

  • Fig. 2 The clinical course during hospitalization and changes in total calcium, ionized calcium, and 25(OH) vitamin D3 levels.


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