J Mov Disord.  2019 May;12(2):120-124. 10.14802/jmd.19006.

The Effect of Globus Pallidus Interna Deep Brain Stimulation on a Dystonia Patient with the GNAL Mutation Compared to Patients with DYT1 and DYT6

Affiliations
  • 1Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. genian@skku.edu
  • 2Neuroscience Center, Samsung Medical Center, Seoul, Korea. krmd.cho@samsung.com
  • 3Samsung Genome Institute, Samsung Medical Center, Seoul, Korea.
  • 4Medical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 5Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea.
  • 6Department of Neurology, Soonchunhyang University Hospital, Gumi, Korea.
  • 7Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract


OBJECTIVE
The aim of this study was to investigate the efficacy of globus pallidus interna deep brain stimulation (GPi-DBS) for treating dystonia due to the GNAL mutation.
METHODS
We provide the first report of a dystonia patient with a genetically confirmed GNAL mutation in the Korean population and reviewed the literature on patients with the GNAL mutation who underwent GPi-DBS. We compared the effectiveness of DBS in patients with the GNAL mutation compared to that in patients with DYT1 and DYT6 in a previous study.
RESULTS
Patients with the GNAL mutation and those with DYT1 had higher early responder rates (GNAL, 5/5, 100%; DYT1, 7/7, 100%) than did patients with DYT6 (p = 0.047). The responder rates at late follow-up did not differ statistically among the three groups (p = 0.278). The decrease in the dystonia motor scale score in the GNAL group was 46.9% at early follow-up and 63.4% at late follow-up.
CONCLUSION
GPi-DBS would be an effective treatment option for dystonia patients with the GNAL mutation who are resistant to medication or botulinum toxin treatment.

Keyword

Deep brain stimulation; GNAL; Dystonia; DYT25

MeSH Terms

Botulinum Toxins
Deep Brain Stimulation*
Dystonia*
Follow-Up Studies
Globus Pallidus*
Humans
Botulinum Toxins
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