Biomed Eng Lett.
2019 Feb;9(1):87-95. 10.1007/s13534-018-0089-9.
Practicality and importance of selected endothelial dysfunction measurement techniques: review
- Affiliations
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- 1College of Engineering, California Polytechnic State University, San Luis Obispo, CA 93407, USA. mdwhitt@calpoly.edu
- 2School of Integrated Studies, Kansas State University, Polytechnic Campus, Salina, KS 67401, USA. mjjackson@ksu.edu
- KMID: 2448399
- DOI: http://doi.org/10.1007/s13534-018-0089-9
Abstract
- The measurement of endothelial dysfunction (ED) has importance in that it indicates the presence of coronary artery disease (Kuvin et al. in J Am Coll Cardiol 38(7):1843-1849, 2001) in addition to acting as a predictor of future adverse events (Halcox et al. in Circulation 106:653-658, 2002). Various tools, methods, and metrics exist that can provide an indicator of endothelial dysfunction. Given the signifi cance of ED, it is of utmost importance to fi nd a measurement technique that is reliable, while defi ning a metric providing a framework for an overall system that is practical, accurate, and repeatable. Success would provide a tool for the early detection of cardiovascular disease not only moving patients that are currently classifi ed as asymptomatic to symptomatic, but also providing a method to monitor the effi cacy of treatments.
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