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Practicality and importance of selected endothelial dysfunction measurement techniques: review

Whitt MD, Jackson MJ

The measurement of endothelial dysfunction (ED) has importance in that it indicates the presence of coronary artery disease (Kuvin et al. in J Am Coll Cardiol 38(7):1843–1849, 2001) in addition...
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Adipose-Derived Stem Cell Transplantation Inhibits Vascular Inflammatory Responses and Endothelial Dysfunction in Rats with Atherosclerosis

Fan M, Bai J, Ding T, Yang X, Si Q, Nie D

PURPOSE: This study aimed to investigate the effect of adipose-derived stem cell (ADSC) transplantation on atherosclerosis (AS) and its underlying mechanisms. MATERIALS AND METHODS: In our study, rat AS model was...
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Effects of Antioxidant Tempol on Systematic Inflammation and Endothelial Apoptosis in Emphysematous Rats Exposed to Intermittent Hypoxia

Zhao H, Zhao Y, Li X, Xu L, Jiang F, Hou W, Dong L, Cao J

PURPOSE: Obstructive sleep apnea and chronic obstructive pulmonary disease are independent risk factors of cardiovascular disease (CVD), and their coexistence is known as overlap syndrome (OS). Endothelial dysfunction is the...
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Active maintenance of endothelial cells prevents kidney fibrosis

Yang SH, Kim YC, An JN, Kim JH, Lee J, Lee HY, Cho JY, Paik JH, Oh YK, Lim CS, Kim YS, Lee JP

BACKGROUND: Soluble epoxide hydrolase (sEH) expressed by endothelial cells catalyzes the metabolism of epoxyeicosatrienoic acids (EETs), which are vasoactive agents. METHODS: We used a unilateral ureteral obstruction mouse model of kidney...
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Intravenous administration of piceatannol, an arginase inhibitor, improves endothelial dysfunction in aged mice

Nguyen MC, Ryoo S

Advanced age is one of the risk factors for vascular diseases that are mainly caused by impaired nitric oxide (NO) production. It has been demonstrated that endothelial arginase constrains the...
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AST-120 Improves Microvascular Endothelial Dysfunction in End-Stage Renal Disease Patients Receiving Hemodialysis

Ryu JH, Yu M, Lee S, Ryu DR, Kim SJ, Kang DH, Choi KB

PURPOSE: Endothelial dysfunction (ED) is a pivotal phenomenon in the development of cardiovascular disease (CVD) in patients receiving hemodialysis (HD). Indoxyl sulfate (IS) is a known uremic toxin that induces...
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Arginase Inhibition Restores Peroxynitrite-Induced Endothelial Dysfunction via L-Arginine-Dependent Endothelial Nitric Oxide Synthase Phosphorylation

Nguyen MC, Park JT, Jeon YG, Jeon BH, Hoe KL, Kim YM, Lim HK, Ryoo S

PURPOSE: Peroxynitrite plays a critical role in vascular pathophysiology by increasing arginase activity and decreasing endothelial nitric oxide synthase (eNOS) activity. Therefore, the aims of this study were to investigate...
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Breakthrough in heart failure with preserved ejection fraction: are we there yet?

Lim SL, Lam CS

Heart failure with preserved ejection fraction (HFPEF) is a global health problem of considerable socioeconomic burden. It is projected to worsen with the aging population worldwide. The lack of effective...
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Salt Sensitivity and Hypertension: A Paradigm Shift from Kidney Malfunction to Vascular Endothelial Dysfunction

Choi HY, Park HC, Ha SK

Hypertension is a complex trait determined by both genetic and environmental factors and is a major public health problem due to its high prevalence and concomitant increase in the risk...
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Expression Profile of Neuro-Endocrine-Immune Network in Rats with Vascular Endothelial Dysfunction

Li L, Jia Z, Xu L, Wu Y, Zheng Q

This study was to determine the correlation between endothelial function and neuro-endocrine-immune (NEI) network through observing the changes of NEI network under the different endothelial dysfunction models. Three endothelial dysfunction...
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Diabetic Retinopathy and Endothelial Dysfunction in Patients with Type 2 Diabetes Mellitus

Yun JS, Ko SH, Kim JH, Moon KW, Park YM, Yoo KD, Ahn YB

BACKGROUND: We investigated the relationship between endothelial dysfunction and diabetic retinopathy (DR) in patients with type 2 diabetes. METHODS: We used a cross-sectional design to examine 167 patients with type 2...
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Oxidative stress is associated with the number of components of metabolic syndrome: LIPGENE study

Yubero-Serrano EM, Delgado-Lista J, Pena-Orihuela P, Perez-Martinez P, Fuentes F, Marin C, Tunez I, Jose Tinahones F, Perez-Jimenez F, Roche HM, Lopez-Miranda J

  • KMID: 2154247
  • Exp Mol Med.
  • 2013 Jun;45(6):e28.
Previous evidence supports the important role that oxidative stress (OxS) plays in metabolic syndrome (MetS)-related manifestations. We determined the relationship between the number of MetS components and the degree of...
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Ovarian stimulation and liver dysfunction: Is a clinical relationship possible? A case of hepatic failure after repeated cycles of ovarian stimulation

Giugliano , Cagnazzo E, Pansini G, Vesce F, Marci R

Liver damage induced by ovarian stimulation has been demonstrated in some cases reported in the literature. However, there has never been a fruitful debate on this topic. The present manuscript...
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Effects of Vitamin D on Blood Pressure and Endothelial Function

Min B

Vitamin D deficiency is prevalent, primarily due to limited sun exposure, which may be observed in urban areas, or as a result of modern lifestyles. Common myths about vitamin D...
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Blood Pressure Variability and Vascular Dysfunction in Essential Hypertension

Okumura K, Cheng XW

  • KMID: 2330956
  • J Korean Soc Hypertens.
  • 2012 Sep;18(3):75-87.
There are several aspects of blood pressure. Clinically, how to best assess blood pressure average and variability is still a matter of the ongoing debate. Besides office blood pressure, we...
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Endothelial arginase II and atherosclerosis

Ryoo S, Berkowitz , Lim HK

Atherosclerotic vascular disease is the leading cause of morbidity and mortality in developed countries. While it is a complex condition resulting from numerous genetic and environmental factors, it is well...
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Endothelial Dysfunction in the Smokers Can Be Improved with Oral Cilostazol Treatment

Kim KS, Park HS, Jung IS, Park JH, Ahn KT, Jin SA, Park YK, Kim JH, Lee JH, Choi SW, Jeong JO, Seong IW

BACKGROUND: Smoking is one of well known environmental factors causing endothelial dysfunction and plays important role in the atherosclerosis. We investigated the effect of cilostazol could improve the endothelial dysfunction...
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Treatment Update on Portal Hypertension and Complications

Lee JW

Current understanding of the pathophysiology of portal hypertension has resulted in therapeutic approaches aimed at correcting the increased splanchnic blood flow and some of which have been already used in...
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Endothelial Function is Not Changed during Short-Term Withdrawal of Thyroxine in Patients with Differentiated Thyroid Cancer and Low Cardiovascular Risk

Chang HJ, Kim KW, Choi SH, Lim S, Park KU, Park DJ, Choi DJ, Jang HC, Cho BY, Park YJ

PURPOSE: The incidence of differentiated thyroid cancer is increasing in young adults and females in Korea. Some of them experience short-term hypothyroidism in preparation for radioiodine (RAI) therapy, which can...
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The Role of Endothelin-1 in Obstructive Sleep Apnea Syndrome and Pulmonary Hypertension

Choi Y

  • KMID: 2317493
  • Sleep Med Psychophysiol.
  • 2010 Dec;17(2):69-74.
Obstructive sleep apnea syndrome is associated with significant cardiovascular morbidity and increased mortality. However, it was controversial whether obstructive sleep apnea syndrome could cause pulmonary hypertension. The controversy was resolved...
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