Ann Pediatr Endocrinol Metab.  2019 Mar;24(1):34-40. 10.6065/apem.2019.24.1.34.

Reference range of random urinary calcium creatinine ratio in North Indian children and adolescents

Affiliations
  • 1Department of Endocrinology and Thyroid Research Centre, INMAS, DRDO, Delhi, India. marwaha_ramank@hotmail.com
  • 2Department of Medicine & Endocrinology, All India Institute of Medical Sciences, Jodhpur, India.
  • 3Dang Laboratory, New Delhi, India.
  • 4Department of Endocrinology, Medanta Hospital, Medicity, Gurugram, India.
  • 5Department of Medicine, Dr B R Sur Homeopathic Medical College, New Delhi, India.
  • 6Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India.
  • 7Central Council of Homeopathic Research, New Delhi, India.

Abstract

PURPOSE
Urinary calcium creatinine ratio (UCaCrR) is a reliable indicator for monitoring hypercalciuria following vitamin D supplementation. However, the reference range varies from region to region. Previous studies did not take vitamin D and parathyroid hormone status into account while evaluating UCaCrR. Hence, we undertook this study to establish the 95th percentile of UCaCrR as an indicator of hypercalciuria in North Indian children and adolescents.
METHODS
Four hundred seventy-three participants (boys 62.2%, girls 37.8%) with adequate dietary calcium intake, normal serum levels of 25-hydroxy-vitamin D (>20 ng/mL), and without secondary hyperparathyroidism following supplementation were selected for evaluation of UCaCrR.
RESULTS
The mean age and body mass index of subjects were 11.2±2.6 years and 18.0±3.6 kg/m2, respectively. The 95th percentile of UCaCrR in the study population was 0.126. The mean, median, and 95th percentile of UCaCrR was significantly higher in prepubertal children (age ≤10 years) (0.0586±0.0374, median=0.0548, 95th percentile=0.136) compared to those >10 years old (0.0503±0.0363, median=0.0407, 95th percentile=0.123, P=0.02). No significant difference in UCaCrR was observed between genders and different weight categories.
CONCLUSIONS
UCaCrR of 0.13 defines the cutoff value for hypercalciuria in North Indian children and adolescents with adequate dietary intake of calcium and sufficient serum vitamin D levels.

Keyword

Urinary calcium creatinine ratio; Children and adolescents; Weight category

MeSH Terms

Adolescent*
Body Mass Index
Calcium*
Calcium, Dietary
Child*
Creatinine*
Female
Humans
Hypercalciuria
Hyperparathyroidism, Secondary
Parathyroid Hormone
Reference Values*
Vitamin D
Calcium
Calcium, Dietary
Creatinine
Parathyroid Hormone
Vitamin D
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