Kidney Res Clin Pract.  2018 Dec;37(4):404-413. 10.23876/j.krcp.18.0064.

Prevalence of dynapenic obesity and sarcopenic obesity and their associations with cardiovascular disease risk factors in peritoneal dialysis patients

• Tabibi H
• As'habi A
• Najafi I
• Hedayati M

• KMID: 2447185
• DOI: http://doi.org/10.23876/j.krcp.18.0064

Abstract

BACKGROUND
Dynapenic obesity and sarcopenic obesity increase cardiovascular disease (CVD) and mortality in nonuremic patients. The present study was designed to determine the prevalence of dynapenic obesity and sarcopenic obesity and their associations with CVD risk factors in peritoneal dialysis (PD) patients.
METHODS
All eligible PD patients in Tehran peritoneal dialysis centers were included in this cross-sectional study. Skeletal muscle mass and fat mass were assessed using bioelectrical impedance analysis. Muscle strength and physical performance were determined using hand grip strength and a 4-meter walk gait speed test, respectively. In addition, a 5-mL blood sample was obtained from each patient.
RESULTS
The prevalence of dynapenic obesity and sarcopenic obesity were 11.4% and 3.8% in PD patients, respectively. Serum high-sensitive C-reactive protein (hs-CRP), soluble intercellular adhesion molecule type 1, triglyceride, total cholesterol, and low-density lipoprotein cholesterol were significantly higher in PD patients with dynapenic obesity than in dynapenic nonobese and nondynapenic nonobese patients. Similarly, serum concentrations of CVD risk factors in PD patients with sarcopenic obesity were higher than in nonsarcopenic nonobese patients, but these differences were statistically significant only for serum hs-CRP and triglyceride. In addition, muscle strength and skeletal muscle mass percentage were negatively associated with markers of inflammation and dyslipidemia, whereas body fat percentage was positively associated with these CVD risk factors.
CONCLUSION
This study indicates that although the prevalence of dynapenic obesity and sarcopenic obesity are relatively low in PD patients, these disorders may be associated with CVD risk factors.

Keyword

Cardiovascular risk factors; Dynapenic obesity; Peritoneal dialysis; Sarcopenic obesity

MeSH Terms

Adipose Tissue
C-Reactive Protein
Cardiovascular Diseases*
Cholesterol
Cross-Sectional Studies
Dicloxacillin*
Dyslipidemias
Electric Impedance
Gait
Hand
Hand Strength
Humans
Inflammation
Lipoproteins
Mortality
Muscle Strength
Muscle, Skeletal
Obesity*
Peritoneal Dialysis*
Prevalence*
Risk Factors*
Triglycerides
C-Reactive Protein
Cholesterol
Dicloxacillin
Lipoproteins