World J Mens Health.  2019 May;37(2):226-233. 10.5534/wjmh.180062.

Metabolic Syndrome Is an Independent Risk Factor for Acquired Premature Ejaculation

• Jeh SU
• Yoon S
• Choi JH
• Do J
• Seo DH
• Lee SW
• Choi SM
• Lee C
• Kam SC
• Hwa JS
• Chung KH
• Kang HW
• Hyun JS

• KMID: 2443238
• DOI: http://doi.org/10.5534/wjmh.180062

Abstract

PURPOSE
To determine the role of metabolic syndrome (MetS) as a risk factor for acquired premature ejaculation (PE) after considering the various risk factors, such as lower urinary tract symptoms, erectile dysfunction, hypogonadism, and prostatitis.
MATERIALS AND METHODS
From January 2012 to January 2017, records of 1,029 men were analyzed. We performed multivariate analysis to identify risk factors for PE, including the covariate of age, marital status, International Prostate Symptom Score, International Index of Erectile Function (IIEF) score, National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) score, serum testosterone levels, and all components of MetS. Acquired PE was defined as self-reported intravaginal ejaculation latency time ≤3 minutes, and MetS was diagnosed using the modified National Cholesterol Education Program Adult Treatment Panel III criteria.
RESULTS
Of 1,029 men, 74 subjects (7.2%) had acquired PE and 111 (10.8%) had MetS. Multivariate analysis showed that the IIEF overall satisfaction score (odds ratio [OR]=0.67, p<0.001), NIH-CPSI pain score (OR=1.07, p=0.035), NIH-CPSI voiding score (OR=1.17, p=0.032), and presence of MetS (OR=2.20, p=0.022) were significantly correlated with the prevalence of acquired PE. In addition, the Male Sexual Health Questionnaire for Ejaculatory Dysfunction scores and ejaculation anxiety scores progressively decreased as the number of components of MetS increased.
CONCLUSIONS
MetS may be an independent predisposing factor for the development of acquired PE. Effective prevention and treatment of MetS could also be important for the prevention and treatment of acquired PE.

Keyword

Metabolic syndrome; Obesity; Premature ejaculation; Risk factors; Sexual dysfunctions; Type 2 diabetes

MeSH Terms

Academies and Institutes
Adult
Anxiety
Causality
Cholesterol
Education
Ejaculation
Erectile Dysfunction
Humans
Hypogonadism
Lower Urinary Tract Symptoms
Male
Marital Status
Multivariate Analysis
Obesity
Premature Ejaculation*
Prevalence
Prostate
Prostatitis
Reproductive Health
Risk Factors*
Testosterone
Cholesterol
Testosterone

Figure

• 

  Fig. 1 The relationship between the number of metabolic syndrome components and the Male Sexual Health Questionnaire for Ejaculatory Dysfunction (MSHQ-EjD) score (mean and 95% confidence interval).

• 

  Fig. 2 The relationship between the number of metabolic syndrome components and the ejaculation anxiety score (mean and 95% confidence interval). *p<0.05 vs. 0 metabolic syndrome components.

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