J Korean Soc Transplant.  2019 Mar;33(1):6-12. 10.4285/jkstn.2019.33.1.6.

Angiotensin II type 1 receptor antibodies in kidney transplantation

Affiliations
  • 1Department of Laboratory Medicine, International St. Mary's Hospital, College of Medicine, Catholic Kwandong University, Incheon, Korea.
  • 2Department of Laboratory Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. ejoh@catholic.ac.kr

Abstract

Angiotensin II type 1 receptor (AT1R) antibodies directly injure endothelial and vascular smooth muscle cells by activating transcription factors associated with proinflammatory responses. Previous studies have shown that AT1R antibodies are associated with allograft rejection and decreased graft survival in kidney transplantation. Development of enzyme-linked immunosorbent assay has facilitated semiquantitative detection of AT1R antibodies. Assessing AT1R antibodies along with donor specific human leukocyte antigen antibodies may have potential to identify patients with possible risk for allograft injury and improve overall outcomes. In this review, we summarize recent clinical studies about AT1R antibodies in kidney transplantation and provide perspectives for future research area.

Keyword

Transplantation; Receptor; Angiotensin, type 1; Kidney

MeSH Terms

Activating Transcription Factors
Allografts
Angiotensin II*
Angiotensins*
Antibodies
Enzyme-Linked Immunosorbent Assay
Graft Survival
Humans
Kidney Transplantation*
Kidney*
Leukocytes
Muscle, Smooth, Vascular
Receptor, Angiotensin, Type 1*
Tissue Donors
Transplantation
Activating Transcription Factors
Angiotensin II
Angiotensins
Antibodies
Receptor, Angiotensin, Type 1

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