- Association Analysis of a Polymorphism of the Angiotensin I-Converting Enzyme Gene and Angiotensin II Type 1 Receptor Gene in Korean Population
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Yang YM
- KMID: 1538081
- J Genet Med.
- 1998 Mar;2(1):27-30.
Previously, we made a study report on the genotype disturbution and the gene frequency of angiotensin I-converting enzyme (ACE) in Korean population, and on the association between hypertension and genetic... -
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- Selection of Antihypertensive Drugs in Hypertensive Patients with Diabetes Mellitus: In Pohang-Gyeongju Primary Care Research Network
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Jang CW, Ha KH, Sung NJ, Lee DW, Cho KR, Jung SH, Choi S, Ki JM, Kim SW, Choi KJ, Kim DI, Song JS, Choi YK, Song HN, Park KH
- KMID: 2182375
- J Korean Acad Fam Med.
- 2006 Sep;27(9):706-712.
BACKGROUND: Angiotensin converting enzyme inhibitor or Angiotensin II type 1 receptor blocker is usually recommended for hypertensive patients with diabetes mellitus. No reports have been made on antihypertensive agents prescribed... -
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- Comparative effects of angiotensin II and angiotensin-(4-8) on blood pressure and ANP secretion in rats
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Phuong HT, Yu L, Park BM, Kim SH
- KMID: 2395262
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):667-674.
- doi: 10.4196/kjpp.2017.21.6.667
Angiotensin II (Ang II) is metabolized from N-terminal by aminopeptidases and from C-terminal by Ang converting enzyme (ACE) to generate several truncated angiotensin peptides (Angs). The truncated Angs have different... -
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- The Effect of an Angiotensin Receptor Blocker on Arterial Stiffness in Type 2 Diabetes Mellitus Patients with Hypertension
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Kim JH, Oh SJ, Lee JM, Hong EG, Yu JM, Han KA, Min KW, Son HS, Chang SA
- KMID: 2175425
- Diabetes Metab J.
- 2011 Jun;35(3):236-242.
- doi: 10.4093/dmj.2011.35.3.236
BACKGROUND: Hypertension and type 2 diabetes mellitus are major risk factors for cardiovascular disease. This study analyzed the changes in central aortic waveforms and pulse wave velocity as well as... -
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- Inducible Nitric Oxide Synthase (iNOS) is Increased in Diabetic Rat Glomeruli: Role of Angiotensin II (AII)
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Choi KH, Noh H, Kim BS, Kang SW, Han DS, Lee HY
- KMID: 1610172
- Korean J Nephrol.
- 2003 Jul;22(4):366-373.
BACKGROUND: This study was designed to examine whether iNOS pathway is pathologically altered in experimental diabetic nephropathy and whether therapy with ACE inhibitor (imidapril: I) or angiotensin II type 1... -
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- Angiotensin converting enzyme I/D, angiotensinogen T174M-M235T and angiotensin II type 1 receptor A1166C gene polymorphisms in Turkish hypertensive patients
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Agachan B, Isbir T, Yilmaz H, Akoglu E
- KMID: 1119337
- Exp Mol Med.
- 2003 Dec;35(6):545-549.
Essential hypertension is a multifactorial disease in which genetic and enviromental factors play an important role. These factors differ in each population. As there are no existing data for the... -
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- Angiotensin II Type 1 Receptor Blocker, Fimasartan, Reduces Vascular Smooth Muscle Cell Senescence by Inhibiting the CYR61 Signaling Pathway
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Kim I, Park CS, Lee HY
- KMID: 2450393
- Korean Circ J.
- 2019 Jul;49(7):615-626.
- doi: 10.4070/kcj.2018.0379
BACKGROUND AND OBJECTIVES: Angiotensin II (Ang II) has been suggested to accelerate vascular senescence, however the molecular mechanism(s) remain unknown. METHODS: We cultured human coronary artery smooth muscle cells (hCSMCs) and... -
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- Differential brain angiotensin-II type I receptor expression in hypertensive rats
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Braga VA
- KMID: 1067403
- J Vet Sci.
- 2011 Sep;12(3):291-293.
- doi: 10.4142/jvs.2011.12.3.291
Blood-borne angiotensin-II (Ang-II) has profound effects in the brain. We tested the hypothesis that Ang-II-dependent hypertension involves differential Ang-II type I (AT1) receptors expression in the subfornical organ (SFO) and... -
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- Polymorphism of the Angiotensin II Type 1 Receptor A1166C in Korean Hypertensive Adolescents
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Lee JA, Sohn JA, Hong YM
- KMID: 2225760
- Korean Circ J.
- 2008 Aug;38(8):405-410.
- doi: 10.4070/kcj.2008.38.8.405
BACKGROUND AND OBJECTIVES: The renin-angiotensin system (RAS) is a major regulator of blood pressure. The angiotensin II receptor type 1 (AGTR 1) A1166C has been extensively studied in searching for... -
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- Evolution and Regulation of Renal Renin and Transforming Growth Factor beta 1 Gene Expression in the Unilateral Ureteral Obstruction of the Neonatal Rat
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Chung KH, Choi H
- KMID: 1914160
- Korean J Urol.
- 1996 May;37(5):493-504.
Unilateral ureteral obstruction(UUO) in early development impairs renal growth. To investigate the potential role of growth-related peptides in this response, Sprague-Dawley rats underwent UUO or sham operation in the first... -
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- A Novel Angiotensin Type I Receptor Antagonist, Fimasartan, Prevents Doxorubicin-induced Cardiotoxicity in Rats
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Chang SA, Lim BK, Lee YJ, Hong MK, Choi JO, Jeon ES
- KMID: 2155468
- J Korean Med Sci.
- 2015 May;30(5):559-568.
- doi: 10.3346/jkms.2015.30.5.559
Angiotensin receptor blockers (ARBs) have organ-protective effects in heart failure and may be also effective in doxorubicin-induced cardiomyopathy (DOX-CMP); however, the efficacy of ARBs on the prevention of DOX-CMP have... -
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- 24-Hour blood pressure response to lower dose (30 mg) fimasartan in Korean patients with mild to moderate essential hypertension
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Lee HY, Kim CH, Song JK, Chae SC, Jeong MH, Kim DS, Oh BH
- KMID: 2396762
- Korean J Intern Med.
- 2017 Nov;32(6):1025-1036.
- doi: 10.3904/kjim.2016.094
BACKGROUND/AIMS: Fimasartan is an angiotensin type 1 receptor blocker (ARB) which has comparable efficacy and tolerability with other ARBs. The aim of this study was to evaluate 24-hour blood pressure... -
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- Angiotensinogen and Angiotensin II Type 1 Receptor Gene Polymorphism in Patients with Autosomal Dominant Polycystic Kidney Disease: Effect on Hypertension and ESRD
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Lee KB, Kim UK
- KMID: 720904
- Yonsei Med J.
- 2003 Aug;44(4):641-647.
- doi: 10.3349/ymj.2003.44.4.641
Autosomal dominant polycystic kidney disease (ADPKD), a common genetic disease, is characterized by the development of hypertension and end stage renal disease. An increase in the activity of the renin-angiotensin... -
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- Clinical Impact of Pre-transplant Antibodies Against Angiotensin II Type I Receptor and Major Histocompatibility Complex Class I-Related Chain A in Kidney Transplant Patients
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Min JW, Lee H, Choi BS, Park CW, Yang CW, Kim YS, Choi YJ, Oh EJ, Chung BH
- KMID: 2434735
- Ann Lab Med.
- 2018 Sep;38(5):450-457.
- doi: 10.3343/alm.2018.38.5.450
BACKGROUND: Evidence of antibody-mediated injury in the absence of donor-specific HLA antibodies (HLA-DSA) has recently emerged, suggesting a role of antibodies in targeting non-HLA antigens expressed on renal allograft tissue.... -
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- Tumor necrosis factor α-converting enzyme inhibitor attenuates lipopolysaccharide-induced reactive oxygen species and mitogen-activated protein kinase expression in human renal proximal tubule epithelial cells
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Bae EH, Kim IJ, Choi HS, Kim HY, Kim CS, Ma SK, Kim IS, Kim SW
- KMID: 2410103
- Korean J Physiol Pharmacol.
- 2018 Mar;22(2):135-143.
- doi: 10.4196/kjpp.2018.22.2.135
Tumor necrosis factor-α (TNFα) and the angiotensin system are involved in inflammatory diseases and may contribute to acute kidney injury. We investigated the mechanisms by which TNFα-converting enzyme (TACE) contributes... -
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- Effect of Central Losartan on DOCA-Salt Hypertension Rats
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Lee SJ, Park CG, Park JS, Kim EJ, Shin SH, Jin DG, Ahn JC, Seo HS, Oh DJ, Ro YM
- KMID: 1938858
- Korean Circ J.
- 2004 Jan;34(1):84-91.
- doi: 10.4070/kcj.2004.34.1.84
BACKGROUND: The purpose of this study was to investigate whether brain AT1 receptor stimulation contributes as a hypertensive mechanism to deoxycorticosterone acetate (DOCA)-salt hypertension. METHODS: 1) Acute injection:Losartan (1 mg/4... -
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- Changes of ZO-1 Expression in Diabetic Rat Glomeruli and Cultured Mouse Podocyte Under High Glucose Conditions and the Effect of Angiotensin II Type 1 Receptor Blocker
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Kim BS, Xu ZG, Park HC, Kang SW, Choi KH, Ha SK, Lee HY, Han DS
- KMID: 2079346
- Korean J Nephrol.
- 2003 Nov;22(6):632-644.
BACKGROUND: Diabetic nephropathy (DN) is clinically characterized by persistent proteinuria. The underlying pathologic changes responsible for the nephropathy are the loss of size selective and/or charge selective properties of the... -
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- Attenuation of Reperfusion Injury with Angiotensin AT1 Receptor Blockade in Rat Myocardial Ischemic Mbdel
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Choi JY, Choi DJ, Ahn H
- KMID: 2062575
- Korean J Thorac Cardiovasc Surg.
- 2001 Mar;34(3):203-212.
BACKGROUND: Although AT1 receptor antagonist can protect myocardium against ischemia/reperfusion injury at the cellular level, the in vivo effect and the mechanisms of this effect have not yet been characterized.... -
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- The Long-Term Clinical Outcomes of Combination Therapy with Angiotensin II Type 1 Receptor Blocker and Simvastatin after Percutaneous Coronary Intervention
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Hong YJ, Jeong MH, Lim SY, Lee SR, Hong SN, Kim KH, Sohn IS, Park HW, Kim JH, Kim W, Ahn Y, Cho JG, Park JC, Kang JC
- KMID: 2227128
- Korean Circ J.
- 2005 Dec;35(12):877-882.
- doi: 10.4070/kcj.2005.35.12.877
BACKGROUND AND OBJECTIVES: Angiotensin II type 1 receptor blocker (ARB) has been to attenuate neointimal formation and vascular smooth muscle cell proliferation, with decreased inflammation. Recent studies have demonstrated that... -
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- Microarray Analysis for Genes Associated with Angiogenesis in Diabetic OLETF Keratocytes
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Park JM, Park YM, Jung W, Lee JE, Lee JS
- KMID: 1789986
- J Korean Med Sci.
- 2014 Feb;29(2):265-271.
- doi: 10.3346/jkms.2014.29.2.265
The purpose of this study was to identify the differences in angiogenesis gene expression between normal and diabetic keratocytes stimulated with interleukin-1alpha (IL-1alpha) and tumor necrosis factor-alpha (TNF-alpha). Primarily cultured... -
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